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Mom's infection may boost epilepsy risk in offspring
Published in Saudi Press Agency on 09 - 05 - 2008


Exposure to certain maternal
infections in the womb increases the odds of epilepsy in
childhood, according to an analysis of data from a Danish
study, according to Reuters.
Among the infections cited were cystitis (inflammation
of the bladder), pyelonephritis (inflammation of the kidney and
upper urinary tract), and vaginal yeast infection.
"If some of these associations are causal, then they could
be related to the infection itself or to its consequences, such
as change in diet or dehydration, and possibly to its
treatment," the research team states.
The study, reported in the May issue of the journal
Pediatrics, involved 90,619 infants born between September 1997
and June 2003 and followed through December 2005.
Lead researcher Dr. Yuelian Sun, from the University of
Aarhus in Denmark, and colleagues identified 646 children who
were diagnosed with epilepsy during up to 8 years of follow-up.
Information about maternal infections was obtained via
telephone interviews during pregnancy. Of the maternal
conditions evaluated, cystitis, pyelonephritis, diarrhea,
coughs lasting longer than 1 week, and vaginal yeast infection
were all linked to epilepsy.
The relative risks ranged from 1.23 for diarrhea to 2.56
for vaginal yeast infections in preterm infants (yeast
infections did not increase the risk in term infants). Prenatal
exposure to cough increased the risk of epilepsy only during
the first year of life.
By contrast, genital herpes, venereal warts, and herpes did
not significantly increase the odds of epilepsy, the
researchers report.
They say that long-term studies based on valid biological
markers of infection would shed more light on the association
between maternal infections and epilepsy risk.


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