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Breakthrough: Gel cuts AIDS chances in women
Published in The Saudi Gazette on 20 - 07 - 2010

For the first time, a vaginal gel has proved capable of blocking the AIDS virus: It cut in half a woman's chances of getting HIV from an infected partner in a study in South Africa. Scientists called it a breakthrough in the long quest for a tool to help women whose partners won't use condoms.
The results need to be confirmed in another study, and that level of protection is probably not enough to win approval of the microbicide gel in countries like the United States, researchers say. But they are optimistic it can be improved.
“We are giving hope to women,” who account for most new HIV infections, said Michel Sidibe in a statement. He is executive director of the World Health Organization's UNAIDS program.
“A gel could “help us break the trajectory of the AIDS epidemic,” he said.
And Dr. Anthony Fauci of the US National Institutes of Health said, “It's the first time we've ever seen any microbicide give a positive result” that scientists agree is true evidence of protection.
The gel, spiked with the AIDS drug tenofovir, cut the risk of HIV infection by 50 percent after one year of use and 39 percent after 2-1/2 years, compared to a gel that contained no medicine.
To be licensed in the US, a gel or cream to prevent HIV infection may need to be at least 80 percent effective, Fauci said.
That might be achieved by adding more tenofovir or getting women to use it more consistently. In the study, women used the gel only 60 percent of the time; those who used it more often had higher rates of protection.
The gel also cut in half the chances of getting HSV-2, the herpes virus that causes genital warts. That's important because other sexually spread diseases raise the risk of catching HIV. Even partial protection is a huge victory that could be a boon not just in poor countries but for couples anywhere when one partner has HIV and the other does not, said Dr. Salim Abdool Karim, the South African researcher who led the study. In the US, nearly a third of new infections each year are among heterosexuals, he noted.
He will present results of the study Tuesday at the International AIDS Conference in Vienna. The research was published online Monday by the journal Science.
“We now have a product that potentially can alter the epidemic trends ... and save millions of lives,” said Dr. Quarraisha Abdool Karim, the lead researcher's wife and associate director of the South African program that led the testing.
The study tested the gel in 889 heterosexual women in and near Durban, South Africa. Researchers had no information on the women's partners, but the women were heterosexual and, in general, not in a high-risk group, such as prostitutes.
Half of the women were given the microbicide and the others, a dummy gel. Women were told to use it 12 hours before sex and as soon as possible within 12 hours afterward.
At the study's end, there were 38 HIV infections among the microbicide group versus 60 in the others.


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