WASHINGTON — Mike Leake outpitched 2016 NL Cy Young Award winner Max Scherzer, Stephen Piscotty homered and had five RBIs, and the St. Louis Cardinals beat the Washington Nationals 6-1 Wednesday to avoid a three-game sweep. Leake (1-1) gave up four hits, struck out seven and walked none over seven shutout innings. The right-hander allowed hits to the first two batters, then picked off a runner before getting 19 straight outs. The streak ended when Daniel Murphy singled with two outs in the seventh. By that time, St. Louis had taken a 3-0 lead against Scherzer, who yielded only one earned run. He did, however, throw three wild pitches - two in the third inning - after tossing only two all last year while going 20-7. Scherzer (1-1) allowed three runs and four hits in six innings. He struck out 10, the 50th time in his career he reached double figures in strikeouts. Orioles 12, Red Sox 5 Trey Mancini hit two of Baltimore's five home runs as the Orioles crushed knuckleballer Steven Wright and the Boston Red Sox 12-5. Mancini hit one of the four home runs yielded by Wright (0-1) in 1 1/3 innings. Mancini hit his fifth homer in 29 major league plate appearances, off reliever Ben Taylor in the third. He has 10 RBIs in 10 major league games. Chris Davis also homered among his three hits while Jonathan Schoop and Adam Jones also went deep for Baltimore. Brewers 2, Blue Jays 0 Chase Anderson allowed three hits in seven innings as Milwaukee shut out Toronto, which is off to the worst start in club history at 1-7. Anderson (1-0) allowed two walks (one intentional) while striking out seven as the Brewers swept the two-game series. The Blue Jays wasted a complete-game effort from right-hander Marcus Stroman (1-1), who allowed seven hits, one walk and two runs, while striking out four in his first complete game since 2014. Dodgers 2, Cubs 0 Andrew Toles homered to lead off the first inning and his hustle in the ninth helped provide the second run as Los Angeles defeated Chicago on a night the Cubs got their World Series rings. Toles took Cubs right-hander John Lackey's third pitch into the right-field bleachers for his first career game-opening homer. Dodgers starter Brandon McCarthy (2-0) worked six strong innings, and three relievers contributed to Los Angeles's first shutout of the season. Yankees 8, Rays 4 Aaron Judge hit a mammoth two-run home run with two outs in the seventh inning as New York rallied to beat Tampa Bay. Judge homered for the third straight game when he drove a 1-1 pitch from Erasmo Ramirez well over the wall in center field and onto the netting above Monument Park. Giants 6, Diamondbacks 2 Starter Matt Cain doubled in the fifth inning to spur a go-ahead, three-run rally as San Francisco beat Arizona. The victory over the hot Diamondbacks meant the Giants avoided dropping a third consecutive series to start the season for the first time since 2007. Astros 10, Mariners 5 Jose Altuve had three hits and scored three times, and Carlos Beltran drove in three runs as Houston shook off a shaky start to beat Seattle. Altuve scored his third run on a two-run double by Beltran in the eighth for the final margin as the Astros totaled 16 hits (13 singles) and overcame a 5-0, third-inning deficit. Houston reached double digits in hits for the second game in a row. Rangers 8, Angels 3 A.J. Griffin allowed four hits over six innings and was supported by three home runs as Texas defeated Los Angeles. Mike Napoli, Elvis Andrus and Carlos Gomez all went deep for Texas, which won for only the third time in eight games. Athletics 8, Royals 3 Andrew Triggs pitched six scoreless innings and Jed Lowrie drove in three runs as Oakland continued its domination of Kansas City. The Athletics extended their winning streak to eight over the Royals and have outscored Kansas City 53-15 in winning their past six games at Kauffman Stadium. Triggs (2-0) has not allowed an earned run in 11 2/3 innings in his two starts. Other results: Braves 5, Marlins 4; Mets 5, Phillies 4; White Sox 2, Indians 1; Tigers 5, Twins 3; Padres 6, Rockies 0; Reds 9, Pirates 2. — Agencies