Al Khaleej stuns Al Hilal with 3-2 victory, ending 57-match unbeaten run    Turki Al-Sheikh crowned "Most Influential Personality in the Last Decade" at MENA Effie Awards 2024    Saudi Arabia arrests 19,696 illegals in a week    SFDA move to impose travel ban on workers of food outlets in the event of food poisoning    GACA: 1029 complaints recorded against airlines, with least complaints in Riyadh and Buraidah airports during October    CMA plans to allow former expatriates in Saudi and other Gulf states to invest in TASI    11 killed, 23 injured in Israeli airstrike on Beirut    Trump picks billionaire Scott Bessent for Treasury Secretary    WHO: Mpox remains an international public health emergency    2 Pakistanis arrested for promoting methamphetamine    Move to ban on establishing zoos in residential neighborhoods    Moody's upgrades Saudi Arabia's credit rating to Aa3 with stable outlook    Al Okhdood halts Al Shabab's winning streak with a 1-1 draw in Saudi Pro League    Mahrez leads Al Ahli to victory over Al Fayha in Saudi Pro League    Saudi musical marvels takes center stage in Tokyo's iconic opera hall    Saudi Arabia and Japan to collaborate on training Saudi students in Manga comics Saudi Minister of Culture discusses cultural collaboration during Tokyo visit    Al Khaleej qualifies for Asian Men's Club League Handball Championship final    Katy Perry v Katie Perry: Singer wins right to use name in Australia    Sitting too much linked to heart disease –– even if you work out    Denmark's Victoria Kjær Theilvig wins Miss Universe 2024    Order vs. Morality: Lessons from New York's 1977 Blackout    India puts blockbuster Pakistani film on hold    The Vikings and the Islamic world    Filipino pilgrim's incredible evolution from an enemy of Islam to its staunch advocate    Exotic Taif Roses Simulation Performed at Taif Rose Festival    Asian shares mixed Tuesday    Weather Forecast for Tuesday    Saudi Tourism Authority Participates in Arabian Travel Market Exhibition in Dubai    Minister of Industry Announces 50 Investment Opportunities Worth over SAR 96 Billion in Machinery, Equipment Sector    HRH Crown Prince Offers Condolences to Crown Prince of Kuwait on Death of Sheikh Fawaz Salman Abdullah Al-Ali Al-Malek Al-Sabah    HRH Crown Prince Congratulates Santiago Peña on Winning Presidential Election in Paraguay    SDAIA Launches 1st Phase of 'Elevate Program' to Train 1,000 Women on Data, AI    41 Saudi Citizens and 171 Others from Brotherly and Friendly Countries Arrive in Saudi Arabia from Sudan    Saudi Arabia Hosts 1st Meeting of Arab Authorities Controlling Medicines    General Directorate of Narcotics Control Foils Attempt to Smuggle over 5 Million Amphetamine Pills    NAVI Javelins Crowned as Champions of Women's Counter-Strike: Global Offensive (CS:GO) Competitions    Saudi Karate Team Wins Four Medals in World Youth League Championship    Third Edition of FIFA Forward Program Kicks off in Riyadh    Evacuated from Sudan, 187 Nationals from Several Countries Arrive in Jeddah    SPA Documents Thajjud Prayer at Prophet's Mosque in Madinah    SFDA Recommends to Test Blood Sugar at Home Two or Three Hours after Meals    SFDA Offers Various Recommendations for Safe Food Frying    SFDA Provides Five Tips for Using Home Blood Pressure Monitor    SFDA: Instant Soup Contains Large Amounts of Salt    Mawani: New shipping service to connect Jubail Commercial Port to 11 global ports    Custodian of the Two Holy Mosques Delivers Speech to Pilgrims, Citizens, Residents and Muslims around the World    Sheikh Al-Issa in Arafah's Sermon: Allaah Blessed You by Making It Easy for You to Carry out This Obligation. Thus, Ensure Following the Guidance of Your Prophet    Custodian of the Two Holy Mosques addresses citizens and all Muslims on the occasion of the Holy month of Ramadan    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.



Experts to design molecule to shut down fat gene
Published in Saudi Press Agency on 07 - 04 - 2010

Scientists in China may have discovered how a gene responsible for obesity kicks into action and want to design a molecule to shut it down, according to Reuters.
The fat mass and obesity-associated gene (FTO) sits on human chromosome 16, and several studies in the past have shown it is strongly linked to weight gain. But scientists are just beginning to figure out how the gene actually works.
"This gene was identified through studies done among different ethnic groups -- Caucasions, Chinese, Japanese and (South) Koreans. It has been established that FTO is associated with obesity," Jijie Chai at the National Institute of Biological Sciences in Beijing told Reuters by telephone.
"We believe that FTO is a good target for treatment of obesity. If we can get an active inhibitor (to shut down the FTO gene), we can work towards some sort of therapy."
In a paper published in the latest issue of Nature, lead researcher Chai and his colleagues described how their study found the FTO gene was only activated when it binds to what are known as "single-stranded DNA".
"It has only activity towards single-stranded DNA and has no activity towards double-stranded DNA," Chai said.
"We want to design a small molecule to block FTO activity, to shut down its function. We can feed this (molecule) to mice and see what happens. If the mice get leaner, that would be very exciting," Chai said, but he added that any therapy for obesity would be years away.
"We are still a long way off in the search of a drug to prevent (or treat) obesity," he said.
The prevalence of obesity is increasing worldwide at an alarming rate and both developed and developing countries are affected, according to the World Health Organisation.
In 2005, some 1.6 billion adults over 15 years old were overweight and at least 400 million adults were obese. WHO projects that by 2015, 2.3 billion adults will be overweight and more than 700 million will be obese.
At least 20 million children under the age of 5 were overweight globally in 2005.
Obesity increases the risk of premature death, diabetes, heart disease, stroke, hypertension and cancer.


Clic here to read the story from its source.