Three trains have collided in southern Pakistan Wednesday morning, killing at least 150 people and injuring 800 more, police and railway officials have said. At least 17 train cars were destroyed in the accident that occurred at 3:40 a.m. local time (22:40 Tuesday GMT) at Ghotki railway station. Police, army and paramilitary forces are assisting in the rescue operation and area hospitals are on emergency notice. The Chairman of Pakistan Railways, Shakil Durani, told CNN there were about 3,000 passengers on the three trains. One train rammed into the back of another after missing a signal, Durani said. This caused several cars to derail, which in turn were struck by another train. The trains involved were the Karachi Express which rammed into the stationary Quetta Express. The derailed carriages were then hit almost simultaneously by a third train, the oncoming Tezgam Express, which was taking passengers from Karachi north to Rawalpindi, near the capital of Islamabad.