MILAN — Teenage Argentine Mauro Icardi scored twice as Serie A leader Juventus slumped to a 2-1 defeat at home to lowly Sampdoria who came from behind to win despite playing for an hour with 10 men Sunday. Juve had won its last four Serie A games, while Sampdoria had lost 10 of its last 13 and only one outcome looked possible after Sebastian Giovinco put the host ahead with a 24th-minute penalty and Sampdoria had Gaetano Berardi dismissed. Instead, Icardi netted twice in the second half as Sampdoria hit back out of the blue. There was a further shock as third-placed Fiorentina went down to its first home defeat of the season, losing 2-0 to relegation-threatened Pescara, and fourth-placed Inter Milan was beaten 3-0 at Udinese as it continued its slump. Goalkeeper Mattia Perin was the hero for Pescara, saving everything Fiorentina could throw at him before Jonathas and Mervain Celik snatched the points by scoring from the visitors' only two real chances. Inter dominated the first hour at Udinese and missed a flurry of chances including one incredible effort from Brazilian Jonathan who contrived to fire wide from six meters in the 54th minute with the goal at his mercy. It paid the price when 35-year-old striker Antonio Di Natale scored twice and Colombian Luis Muriel was also on target in the closing half hour. Inter's unhappy afternoon was complete when defender Juan Jesus sent off for a second bookable offense. Juventus, with 44 points from 19 games, still reached the halfway mark in the championship with a five-point lead over Lazio, which beat Cagliari 2-1 Saturday. Fiorentina and Inter has 35 points. In other matches, two goals by Marco Boriello gave Genoa a 2-0 win over Bologna which lifted it out of the relegation zone while Bojan Krkic and Giampaolo Pazzini scored to give seventh-placed AC Milan a 2-1 win at home to bottom club Siena. Chievo Verona beat Atalanta 1-0 in a midtable clash and a stoppage-time goal from Amauri gave Parma a 2-1 win over Palermo which left the Sicilians one place off the bottom with 15 points, one below Cagliari and two adrift of 17th-placed Genoa. Lyon knocked out In Paris, holder Lyon, currently flying high in Ligue 1, was sensationally knocked out of the French Cup Sunday in a penalty shoot-out with third division club Epinal. The round-of-64 match had ended 3-3 after extra-time, and Epinal went on to spring the biggest upset of the weekend when it beat the seven-time French league champion 4-2 on penalties. — Agencies