LONDON — Humbled by Celtic in the latest shock result in the Champions League, Barcelona travels to Russia this week as the competition favorite attempts for the second time to seal a place in the knockout stage. The Champions League has thrown up a string of unpredictable scorelines this season and none bigger than Barca's 2-1 loss in Glasgow two weeks ago, preventing the Spanish giant joining FC Porto, Malaga and Manchester United in the last 16 with two games to spare. Lionel Messi and his team still needs one more victory to advance in Group G but achieving that at Spartak Moscow Tuesday is far from guaranteed, given that Barcelona has won only once in six trips to Russia. “We must not drop our guard or relax,” said Barcelona playmaker Andres Iniesta. “Up to this point, our start to the season has been sustained and sensational. But we must continue as we've begun.” While Barcelona is still a big favorite to progress, the same can't be said of a number of Europe's big guns. Manchester City has been on the cusp of elimination for a month now and the fate of the English champion, which is bottom of Group D on just two points from four games, will be sealed if it fails to beat Real Madrid at home Wednesday in the most high-profile clash of the fifth round of group games. A win for Madrid would likely take it through, although Jose Mourinho's side is also stumbling after picking up just one point from its double-header with silky German side Borussia Dortmund. “We will play with practically our season on the line,” Madrid defender Sergio Ramos said. “As a football player, those are the kind of games you live for.” Dortmund is the group leader and needs only a point at Ajax to advance. Chelsea is engaged in a tough three-way fight for the two qualification spots in Group E, and a loss in Juventus Tuesday will leave the holder's destiny out of its hands. Only one point separates Chelsea, Juventus and group leader Shakhtar Donetsk, which could qualify with a win at FC Nordsjaelland. AC Milan needs a win in Anderlecht Wednesday if the struggling Italian side does not want to face the serious prospect of elimination from Group C, while the winner of Tuesday's match between Valencia and last season's runner-up Bayern Munich will qualify in Group F. Paris Saint-Germain requires just a point at Dynamo Kiev to join FC Porto in the next round from Group A, while Schalke and Arsenal will qualify from Group B if they beat Olympiakos and Montpellier, respectively. Messi, the prolific Argentina forward, has tried to make Barcelona forget about its disappointment in Scotland by maintaining his remarkable run of scoring form. His double in the 3-1 win at Real Zaragoza Saturday took his 2012 tally to 78 in 2012, moving within seven of former Germany striker Gerd Mueller's all-time record of goals in a calendar year, set in 1972. Last week, Messi scored another double to move past Pele into second place (75 goals in 1958). However, coach Tito Vilanova has made a point of saying his squad's success is more down to teamwork than the individual brilliance of its star player. Barca has already spoken of Messi's hunger to beat Raul Gonzalez's tally of 71 goals as the all-time highest scorer in the Champions League. Currently, Messi is third with 54, behind Ruud van Nistelrooy (56). Vilanova welcomed back the central-defensive pairing of Gerard Pique and Carles Puyol at the weekend, which should shore up a back line that looked exposed against Celtic. — AP