Rookie right-hander Zach Eflin pitched a three-hitter Friday to lift the Philadelphia Phillies past the Pittsburgh Pirates 4-0 at PNC Park. Eflin struck out six and walked none in his first career shutout and second career complete game. He threw 100 pitches and faced just two Pirates batters over the minimum. He has a string of six starts in which he hasn't given up more than three earned runs while going at least six innings. Mariners 2, Blue Jays 1: James Paxton struck out nine over seven innings, Seth Smith doubled in the go-ahead run in the fifth inning and Seattle defeated Toronto. Paxton, a left-hander, allowed three hits, including a home run, one walk and one run in the opener of a three-game series. Orioles 5, Indians 1: Mark Trumbo hit a three-run homer in the first and Manny Machado added a solo shot in the third as Baltimore scored victory over Cleveland. Trumbo's blast was his 29th of the season and Machado's solo shot — his 20th — stretched the lead to 5-0. Both homers came off Cleveland starter Trevor Bauer. Twins 2, Red Sox 1: Miguel Sano's RBI double in the sixth inning provided just enough offense for Minnesota in a win over Boston at Fenway Park. Sano collecting three hits and Brain Dozier added his 17th homer of the year for the Twins. Twins starter Kyle Gibson tossed eight one-run innings for the victory, allowing two hits and a walk while striking out six. Padres 5, Nationals 3: Matt Kemp hit two home runs and had four RBIs and Luis Perdomo, in the longest start of his short career, allowed just two runs in seven innings as San Diego beat Washington. Kemp, who has 22 homers, now has nine multi-homer games in his career and two this season. He has six homers in the last five games and is one homer shy of the 23 he hit last season. Mets 5, Marlins 3 Jose Reyes, playing his first game in Marlins Park since 2012, had a major role in three New York rallies in a win over Miami. James Loney added a two-run homer in the ninth, turning on a 95-mph fastball from reliever Fernando Rodney and pulling it to the upper deck in right field. He drove in Yoenis Cespedes, who was hit by a pitch with two outs. Yankees 3, Giants 2: Chase Headley scored the tiebreaking run in the eighth inning on a throwing error by shortstop Brandon Crawford as New York overcame a hiccup by part of its late-inning relief trio and picked up a win over San Francisco. The winning run scored on what seemed a certain double play when Austin Romine hit a chopper off Josh Osich over the mound and Crawford easily stepped on second to get the force on Mark Teixeira. Headley advanced to third on the force and when Crawford's throw sailed off first baseman Brandon Belt's glove, Headley raced home and got his left foot on the plate just ahead of the tag. Reds 6, Diamondbacks 2: Joey Votto hit a three-run homer and Tucker Barnhart added a solo shot, lifting Cincinnati over Arizona at Great American Ball Park. Jean Segura got Arizona off to a good start with a home run leading off the game. But the Diamondbacks couldn't hold the early lead. Royals 3, Rangers 1: Danny Duffy threw 6 2/3 solid innings and Cheslor Cuthbert homered as Kansas City bested struggling Texas. Duffy, who did not move into the rotation until May 15, yielded one run on four hits over 6 2/3 innings. He is 5-0 in his past eight starts and has pitched into the seventh inning in his last five starts. Astros 2, Angels 1: Lance McCullers carried a shutout into the ninth inning in Houston's win over Los Angeles at Minute Maid Park. McCullers allowed four hits and four walks while striking out a season-high-tying 10 batters. After escaping trouble in the fifth inning with a double play, McCullers retired nine consecutive batters, including striking out the side in the eighth, before issuing a pair of walks to open the ninth. Cubs 5, Brewers 2: Dexter Fowler had four hits in his return from a six-week stint on the disabled list and Jason Hammel threw six solid innings to lead Chicago over Milwaukee at Miller Park. Hammel allowed a pair of runs on four hits and a walk with a pair of strikeouts and earned a victory in consecutive starts for the first time since May 2. Other results: Tigers 7, White Sox 5; Rockies 4, Braves 3; Cardinals 4, Dodgers 3 (16 innings); Athletics 1, Rays 0.