Scores of people were feared buried alive Saturday after two powerful quakes hit southern Japan a day apart, killing at least 41 people, and as a forecast storm threatened more devastating landslides. Homes, roads and railway lines were swept away when huge hillsides collapsed, as thousands of tonnes of mud was dislodged by the thunderous seismic tremors. Buildings were reduced to rubble, including a university dormitory and apartment complexes, with dozens of people unaccounted for over a wide area. "We are aware of multiple locations where people have been buried alive," chief cabinet secretary Yoshihide Suga told a press conference. "Police, firefighters and Self Defense Force personnel are doing all they can to rescue them." Around 70,000 people have been evacuated, including 300 from an area close to a dam thought to be at risk of collapse. A hospital was left teetering by Saturday morning's 7.0 quake, with doctors and patients rushed from the building in darkness. Isolated villages in the mountainous area of Kumamoto were completely cut off by landslides and damage to roads, with at least 1,000 people believed trapped in one area alone. Aerial footage showed a bridge on a main trunk road had crashed onto the carriageway below it, its pillars felled. The quake came as emergency responders were working to reach areas already affected by a 6.2 magnitude tremor that struck late Thursday. Adding to worries was the eruption of a nearby volcano, although seismologists cautioned there was no evidence of a link and said activity was limited. Aftershocks continued to rock Kumamoto and its surroundings, an area unaccustomed to the powerful quakes that regularly shake other parts of seismically-prone Japan. Thursday's initial quake affected older buildings and killed nine people, but Saturday's brought newer structures crashing down, including a municipal office in the city of Uto. "The total number of deaths rose to 41," Yumika Kami, a spokeswoman at the Kumamoto prefectural government, said. Nearly 1,000 people have been hurt, 184 of them seriously, she added. Tokai University announced that two of its students, who were among around a dozen trapped in a dormitory building in Minami-Aso, were now known to have died. "We offer our sincerest prayers for the two," said a statement on its website. "We're trying to confirm the safety of other students." At least one of those who died was killed when a fire ripped through an apartment complex in the town of Yatsushiro, a local official said. In nearby Kumamoto city, a journalist said he was jolted awake by powerful shaking, which sent the television set in his hotel room crashing to the floor. Staff urged guests to evacuate. Kumamoto airport was forced to close after a ceiling collapsed, Jiji Press reported, with no immediate plans to resume flights, and communications in the area were spotty. Nearly 400,000 households were without a water supply, and electricity was cut off in 170,000, the government earlier said. Japan Meteorological Agency official Gen Aoki said Saturday's quake was the strongest to hit in recent days, and that Thursday's was merely a "precursor." The agency said rain was expected to hit Kumamoto from Saturday evening, and some areas would see heavy downpours on Sunday, raising the risk of further landslides in places where soil and rock has already been loosened. The town of Misato advised more than 10,000 people to evacuate on Saturday over fears of a landslide, national broadcaster NHK reported. Prime Minister Shinzo Abe announced he was sending 20,000 emergency responders to the area, including troops, firefighters and medics. "From tonight, we are expecting rain and winds and deteriorating weather in the Kyushu region," he told a press conference. "There are fears of possible landslides and other secondary disasters. "The time is now. What we can do during daylight will be key." Japan, one of the most seismically active countries in the world, suffered a massive undersea quake on March 11, 2011 that sent a tsunami barreling into the country's northeast coast. Some 18,500 people were left dead or missing, and several nuclear reactors went into meltdown at the Fukushima plant in the worst atomic accident in a generation. Japan's only working nuclear plant, which is southwest of Saturday's quake epicenter, was unaffected, the government has said. Tremors breach the historic walls of 400-year old Kumamoto Castle The deadly earthquakes that struck the southern Japanese island of Kyushu on Thursday and Saturday breached the walls of Kumamoto Castle which had previously withstood bombardment and fire in its four centuries of existence. The fortification in the city of Kumamoto has stood as one of Kyushu's icons ever since it was built in 1607 by Kiyomasa Kato. He was a veteran military campaigner and feudal lord who took part in the reunification of Japan, which had been ravaged by a century of war. Television footage on Saturday showed a large section of the stone wall housing the castle collapsed in a dusty heap. A powerful 7.3 magnitude earthquake struck southern Japan early on Saturday, killing at least 20 people, injuring more than 1,000 and trapping people in collapsed buildings, barely a day after Thursday's quake killed nine people in the same region. While the castle keep, which has so far withstood the series of quakes, is a concrete reconstruction built in 1960, many of the stone walls are originals from the 17th century. Sections of the outer stone walls had already been damaged by Thursday's earthquake. Long after advancements in firearms made such fortifications obsolete, the castle withstood artillery fire when it came under siege from a rebel samurai army during the Satsuma Rebellion of 1877. Much of the castle structure later burned down during the conflict, although the walls managed to stand firm. Now a popular tourist attraction, the castle's administrative office has closed the structure to the public. "Please do not go close to the stone walls as aftershocks continue," the office said on its Facebook page.