Spencer Ware and Michael Ford ran for two scores apiece and second-ranked LSU overwhelmed Northwestern State 49-3 Saturday night. LSU (2-0) led 28-3 by halftime, allowing coach Les Miles to give a number of starters some rest in advance of the Tigers' next game at Mississippi State Thursday night. Coveted junior college transfer quarterback Zach Mettenberger made his debut in relief of LSU starter Jarrett Lee to open the second half. No. 5 Florida State 62, Charleston Southern 10: In Florida, EJ Manuel threw for a career-best 329 yards and four touchdowns as No. 5 Florida State defeated Charleston Southern in a tune-up for next week's showdown against top-ranked Oklahoma. The Buccaneers didn't complete a pass or have a first down in the first half, and trailed 34-0. Manuel hit Bert Reed on two short TD passes while the Seminoles' defense limited Charleston Southern to 84 total yards. No. 6 Stanford 44, Duke 14: Andrew Luck matched a career high by throwing four touchdown passes in No. 6 Stanford's rout of Duke. Luck was 20 of 28 for 290 yards with touchdown passes of 60 and 3 yards to Coby Fleener, 10 yards to Chris Owusu and 3 yards to Zach Ertz. Stanford (2-0) won its 10th straight game dating to last season and claimed a rare regular-season win on the East Coast while denying the Blue Devils (0-2) their first Top 25 win since 1994. No. 8 Wisconsin 35, Oregon State 0 : In Wisconsin, Russell Wilson threw three touchdowns and No. 8 Wisconsin overcame a slow start from its running game to beat Oregon State at Camp Randall Stadium. With Oregon State's defense stuffing running backs Montee Ball and James White early on, Wisconsin pounced on special teams mistakes and leaned on Wilson and the defense to do the rest. In his second career start for the Badgers (2-0), Wilson was 17 of 21 for 189 yards and the three touchdowns, including a pair to tight end Jacob Pedersen. Wisconsin's running game broke through after halftime, and Ball had a pair of touchdowns in the second half. No. 10 Nebraska 42, Fresno State 29: In Nebraska, Ameer Abdullah returned a kickoff 100 yards after Fresno State made it a two-point game in the fourth quarter, and Taylor Martinez's 46-yard touchdown run secured the 10th-ranked Cornhuskers' victory. Martinez ran 15 times for 166 yards and two TDs and passed for another as the Huskers turned back an upset bid by the Bulldogs, who were four-touchdown underdogs. Derek Carr threw incomplete to a well-covered A.J. Johnson on a 2-point try after his 26-yard TD pass to Josh Harper pulled the Bulldogs to 28-26. No. 11 Virginia Tech 17, East Carolina 10: Josh Oglesby ran for the go-ahead 10-yard score with 7:30 left, helping No. 11 Virginia Tech beat East Carolina to give coach Frank Beamer his 200th win at the school. In other games it was: No. 13 Oregon 69, Nevada 20; No. 14 Arkansas 52, New Mexico 3; No. 15 Ohio State 27, Toledo 22; Auburn 41, No. 16 Mississippi State 34; No. 17 Michigan State 44, FAU 0; No. 18 Florida 39, UAB 0; No. 19 West Virginia 55, Norfolk State 12; No. 22 South Florida 37, Ball State 7.