Major U.S. airlines canceled more than 5,000 flights on Wednesday for a second straight day as a monster winter storm slammed large parts of the nation and paralyzed air travel to and from major cities. The storm blasted the Northeast and the Midwest, where the blizzard was on track to dump the most snow in more than 40 years, Reuters reported. Flightaware.com, a website that tracks flights, estimated total U.S. cancellations of 5,280 as of early Wednesday. United Airlines, Delta Air Lines Inc and American Airlines all suspended operations at Chicago O'Hare International Airport, the second-busiest airport in the United States. "We're totally out of Chicago today, 920 cancellations in and out," said American Airlines spokesman Tim Smith. "Operations in New York (are) ramping up somewhat this afternoon," Smith said. Atlanta-based Delta said its operations were canceled at both O'Hare and Midway airports in Chicago, and added it expects to return to normal operations in Chicago on Thursday.