Afghan President Hamid Karzai has ordered an investigation into a U.S.-led coalition air strike that local officials say killed 15 civilians. Karzai ordered the Defense and Interior Ministries and a body that oversees local government to investigate, a statement from the presidential palace said on Sunday. "President Hamid Karzai has repeatedly emphasized the (need for) coordination of military operations and has been deeply saddened since learning about this incident," the statement was quoted as saying by Reuters. Both the NATO-led International Security Assistance Force (ISAF) and U.S.-led coalition forces say they take the utmost care to avoid killing civilians and ISAF tightened procedures for launching airstrikes a year ago, which has had some effect.