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Low vitamin D may harm the bones of IBD patients
Published in Saudi Press Agency on 03 - 07 - 2008


Maintaining adequate vitamin D
levels in the body may help guard against bone disease in
patients with inflammatory bowel disease (IBD), according to a
study in which researchers found a link between inadequate
vitamin D levels and lower bone mineral density in a group of
IBD patients, according to Reuters.
IBD refers to the inflammation of the large or small colon
and is characterized by diarrhea, abdominal pain and cramping,
bloody stool, weight and appetite loss, and ulceration of the
bowel lining. Crohn's disease and ulcerative colitis are two
common types of inflammatory bowel disease.
A higher incidence of osteoporosis and fractures is a
recognized complication of IBD, but the role of vitamin D
insufficiency in IBD-related bone disease is uncertain.
Dr. William D. Leslie and colleagues from the University of
Manitoba, Winnipeg, Canada, identified adults recently
diagnosed with IBD and measured bone mineral density and
vitamin D levels in a subgroup of 101 subjects.
Only 22 (22 percent) had optimal vitamin D levels, they
found. Six patients, or 6 percent, had deficient levels, 38 (38
percent) had insufficient levels, and 35 (35 percent) had
marginal levels.
Higher vitamin D levels were associated with greater bone
density; lower levels with reduced bone density.
In 94 of the 101 subjects who had repeat BMD measurements
roughly 2 years later, researchers saw a positive correlation
between a gain in BMD in that interval and vitamin D levels.
"Early optimization of vitamin D may help to prevent bone
disease in inflammatory bowel disease," Leslie commented to
Reuters Health.
His group's next step, he said, "is to see whether poor
vitamin D status or the degree of activity in a patient's
inflammatory bowel disease lead to progressive loss in bone
density."


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