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Doctor admits leaking research study that tied diabetes
Published in Saudi Press Agency on 30 - 01 - 2008


A Texas doctor leaked confidential
research to the makers of the popular diabetes drug Avandia
weeks before a study was published tying the drug to higher
heart risks, the scientific journal Nature reported
Wednesday, according to The Associated Press.
Dr. Steven Haffner, of the University of Texas Health
Science Center at San Antonio, broke confidentiality rules
for medical journal peer reviewers when he gave the Avandia
study to GlaxoSmithKline PLC 17 days before it was
published in the New England Journal of Medicine, the
Nature report says.
The study, linking Avandia to a 43 percent greater risk of
heart attacks, got widespread attention, led the federal
Food and Drug Administration to issue a safety alert, and
caused the company's stock to drop. The study was led by
Cleveland Clinic cardiology chief Dr. Steven Nissen.
Haffner admitted faxing the study to a Glaxo employee he
worked with on an earlier Avandia study, says the report
published online Wednesday in the news section of Nature.
«Why I sent it is a mystery. I don't really understand
it. I wasn't feeling well. It was bad judgment,» Nature
quotes Haffner as saying.
It's not clear that Glaxo took any action after getting
the confidential information. Most scientific journals have
outside scientists, «peer reviewers,» who study research
to be sure it is solid before it is published.
The leak came to light last summer, when Glaxo officials
informed the Senate Finance Committee that Haffner had sent
them the study, according to a letter released Wednesday by
Republican Sen. Charles Grassley, the panel's ranking
member. Grassley wants Glaxo to explain what it did after
learning that the negative study was imminent.
Glaxo spokeswoman Nancy Pekarek told Nature that the
company did not offer any input to Haffner on the study
and, to her knowledge, did not inform the New England
Journal of the breach, the Nature article says.
Spokesmen for the New England Journal would not say what
if any actions had been taken against Haffner.
«We consider the peer-review process to be confidential.
Any breach of ethics by a reviewer would be taken very
seriously by the editors, but would be handled as a private
matter,» says a statement from the journal.
Last year, the journal restricted future publishing rights
of another peer reviewer, Columbia University's Dr. Martin
Leon. He had discussed confidential results of another
controversial study, involving angioplasty and heart
stents, before its scheduled publication.


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