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Smoking may worsen knee arthritis
Published in Saudi Press Agency on 11 - 12 - 2006


Smokers with knee arthritis
suffer quicker joint deterioration than non-smokers with the
condition, a new study suggests, Reuters reported.
Researchers found that among 159 men with knee arthritis,
smokers reported more pain and were more than twice as likely
to show significant cartilage loss in the joint.
Cartilage is the elastic tissue that cushions the ends of
the bones; in osteoarthritis -- the common "wear-and-tear" form
of arthritis -- this cartilage gradually breaks down, leading
to inflammation, pain and deformity in the bones.
Some past studies, though not all, have suggested that
smokers might be at greater risk of osteoarthritis. The current
one, published online by the Annals of the Rheumatic Diseases,
suggests that when smokers do develop the condition, it may be
more severe.
The findings are "provocative" and should spur further
research, write the study authors, led by Dr. Shreyasee Amin of
the Mayo Clinic College of Medicine in Rochester, Minnesota.
The 159 men with knee osteoarthritis in the study were
followed for 2.5 years. The researchers used MRI scans to
measure cartilage loss in the knee at the beginning, midpoint
and end of the study. The men also rated their knee pain at
each follow-up visit.
In general, Amin's team found, the 12 percent of men who
were smoking at the study's outset showed greater cartilage
loss over time and reported more pain than their non-smoking
counterparts. This was despite the fact that the smokers tended
to be younger and weigh less, which might be expected to delay
progression of their arthritis.
There are a number of reasons smoking could exacerbate
arthritis, according to the researchers. For one, they note,
smoking can deprive tissue of oxygen, which might hinder normal
cartilage repair. In addition, since cartilage itself has no
pain fibers, it's possible that smokers' greater pain comes
from damage to other structures in the arthritic joint.


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