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Study questions radiation after prostate removal
Published in Saudi Press Agency on 14 - 11 - 2006


Using radiation to try to
halt the spread of advanced prostate cancer after the gland
itself has been surgically removed does not appear to add much
to overall survival rates, a study said on Tuesday, according to Reuters.
About a third of the 230,000 cases of prostate cancer
diagnosed in the United States each year result in removal of
the gland, and of those the cancer has spread in 38 to 52
percent of patients, said the report from the University of
Texas Health Science Center in San Antonio.
For the past four decades, radiation treatments have often
been used in cases where the cancer has spread but the effect
of such therapy on survival has not been tracked, said the
report published in this week's Journal of the American Medical
Association.
The Texas researchers said they looked at 425 men with
cancer beyond the prostate after the gland had been removed
from 1988 to 1997. About half of the men were treated with
radiation beam therapy and the others were not.
At the end of the study 71 in the radiation group had died
compared to 83 in the non-radiation group, a difference not
considered significant, the study said.
In another prostate-related study in the same issue,
researchers at the Urological Sciences Research Foundation and
the University of California, Los Angeles, reported that
testosterone treatments to combat what is sometimes called male
menopause do not appear to complicate prostate problems also
common in older men.
The finding was based on 44 men with low blood levels of
testosterone, some of whom were given injections of the hormone
while others received an inert substance.
After six months of treatment, no changes were observed in
their prostates or in cancer incidence or severity and there
were only slight changes in urination-related problems, said
the study.
"These preliminary data suggest that in aging men with
late-onset hypogonadism (reduced secretion of hormones from sex
glands), six months of testosterone replacement therapy
normalizes serum androgen levels but appears to have little
effect on prostate tissue androgen levels and cellular
functions," the report said.
It added that establishing safety generally would require
tests on a larger scale.
Blood testosterone levels decline with age, and many older
men may as a result suffer depression, sexual dysfunction,
diminished lean body mass, muscle volume and strength and
reduced bone mineral density -- changes that have sometimes
been called male menopause, the study said.


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