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HK scientists identify cancer-blocking protein
Published in Saudi Press Agency on 26 - 10 - 2006


Scientists in Hong Kong have
identified a protein that can help suppress the growth of
prostate cancer cells, the third most common cancer in men
worldwide, REPORTED REUTERS.
With half a million new cases a year, prostate cancer
afflicts one in every six men in the United States and one in
50 males in Hong Kong.
But current therapies for advanced prostate cancer, such as
chemotherapy, are far from satisfactory and carry side effects.
In a study first published online in the July issue of
Endocrinology, researchers at the University of Hong Kong found
that human prostate cancer cells produce a protein called
sPDZD2.
The researchers found that when the protein was blocked in
laboratory mice, prostate cancer cells in the rodents grew more
quickly, and vice versa.
The results of the research were officially announced on
Thursday and will appear in the printed version of the journal
in November.
Yao Kwok-ming, biochemistry assistant professor, explained
that sPDZD2 influences the production of p53, a human protein
that is widely known to suppress tumours.
"P53 is produced by all cells but the amount varies. When
it senses stress signals, more of it will be produced. In the
absence of stress, the level of p53 is very low," Yao said.
"SPDZD2 ... turns on p53. More p53 is produced and there is
a slowing down of the growth of these cancer cells."
The finding might pave the way for the making of a new drug
but that is not expected to materialise anytime soon.
"It would take at least 10 years," said Stephen Shui,
physiology associate profession at the University of Hong Kong.
Yao added: "We want (the drug) to mimic the effect of
sPDZD2. We want to turn on the pathway so more p53 can be made.
It is the guardian angel and it can slow down (cancer) cell
cycle progression."


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