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Scientists identify agent that regulates appetite
Published in Saudi Press Agency on 01 - 10 - 2006

Scientists in Japan have
identified a molecule responsible for making mammals feel full, a
discovery that could lead to new ways to treat obesity in humans, according to Reuters.
Scientists believe appetite is controlled in a region of the
brain called the hypothalamus, and the group of researchers
claims to be the first to pinpoint an agent that triggers an
increase or decrease in appetite.
In an article published on Sunday in the online version of
the journal Nature, the scientists identified the molecule as
nesfatin-1, which is produced naturally in the brain.
After injecting the molecule into the brains of rats, the
scientists observed that the rodents began to eat less and lose
weight.
The researchers also were able to induce the rats to eat
more, by blocking nesfatin-1.
"After we injected anti-nesfatin-1 antibody, these rats
showed increased appetite and finally showed a progressive
increase in body weight," Masatomo Mori of the medicine and
molecular science department at Gunma University Graduate School
of Medicine told Reuters in a telephone interview.
Mori said the finding could pave the way for treating
obesity, which has become a major health problem in the
developing world as well as in economically advanced countries.
There are at least a billion overweight adults across the
world, 300 million of them considered obese, according to the
World Health Organisation.
Obesity has been linked to chronic diseases, such as type 2
diabetes, cardiovascular disease, hypertension and stroke, and
some forms of cancer.


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