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Nicotine tablets help COPD patients quit smoking
Published in Saudi Press Agency on 24 - 08 - 2006


Nicotine replacement therapy
enables a significant number of patients with chronic
obstructive pulmonary disease (COPD) to stop smoking, according
to a report in the August issue of Chest, Reuters reported.
"Nicotine replacement therapy works in COPD," Dr. Philip
Tnnesen from Gentofte Hospital, Hellerup, Denmark, told
Reuters Health. "And nicotine replacement therapy works in
smokers of fewer than 10 cigarettes per day. I believe this is
the first study ever to show this."
COPD is a group of serious lung diseases that include
emphysema and chronic bronchitis. It is primarily caused by
smoking.
Tnnesen and colleagues compared the efficacy of nicotine
replacement combined with high- or low-behavioral support for
smoking cessation in 370 patients with COPD who smoked an
average of about 19 cigarettes daily.
The use of under-the-tongue nicotine tablets was associated
with an approximate doubling of abstinence rates compared with
placebo at 6 (23 percent versus 10 percent) and 12 months (17
percent versus 10 percent), respectively, the authors report.
However, the intensity of behavioral support did not
significantly influence the outcomes.
"The good thing from our design is that both the
interventions used seem to be effective," Tnnesen said.
Neither nicotine replacement nor behavioral support
significantly influenced smoking reduction among patients who
continued to smoke after 6 or 12 months, the results indicate.
Smoking cessation was associated with a significant
increase in lung function, the investigators say, whereas lung
function remained stable among those who reduced their smoking
but deteriorated among those who continued smoking at their
baseline rate.
Adverse events occurred at similar rates in the nicotine
and placebo groups and in the high- and low-behavioral support
groups.
"We must get our COPD patients to quit smoking," Tnnesen
said, adding "smoking cessation should be an integral part of
therapy for patients who smoke with respiratory disease."


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