Literature Commission inaugurates Saudi Pavilion at Muscat Book Fair    Saudi Minister of Culture holds talks with his Costa Rican counterpart in Jeddah    Saudi Arabia cracks down on fraudulent Hajj campaigns, urges pilgrims to use official channels    Nammos Amala Resort to open soon with Saudi-Greek designs    Saudi Arabia completes 674 Vision 2030 initiatives, achieves 93% of KPIs as ninth-year milestone marked    MHRSD: 80% of recruitment offices are non-compliant with regulations    GACA chief chairs 16th meeting of the Steering Committee on aviation's strategy    Alkhorayef praises advancements in Al-Kharj food industries sector    At least 50 Palestinians killed in Israeli strikes across Gaza    Teenage girl killed in French school stabbing attack    Trump claims meeting with China after Beijing denies any trade negotiations    Police fatally shoot man at Toronto's international airport    Saudi Theater Commission launches its Work and Learn Project in UK    The season has begun — and one comment shook us all    Jennifer Lopez dazzles in Jeddah with a Formula 1 performance    Saudi Arabia open to expanded 64-team World Cup in 2034, says sports minister    Average life expectancy in Saudi Arabia rises to78.8 years    Super Max Verstappen scorches to pole with record lap in Jeddah    Film Commission launches 'Cinema' initiative to enhance content    Famed Philippine film star Nora Aunor dies at 71    Pakistani star's Bollywood return excites fans and riles far right    Veteran Bollywood actor Manoj Kumar dies at 87    Bollywood actress vindicated over boyfriend's death after media hounding    Grand Mufti rules against posting prayers and preaching in mosques on social media    Exotic Taif Roses Simulation Performed at Taif Rose Festival    Asian shares mixed Tuesday    Weather Forecast for Tuesday    Saudi Tourism Authority Participates in Arabian Travel Market Exhibition in Dubai    Minister of Industry Announces 50 Investment Opportunities Worth over SAR 96 Billion in Machinery, Equipment Sector    HRH Crown Prince Offers Condolences to Crown Prince of Kuwait on Death of Sheikh Fawaz Salman Abdullah Al-Ali Al-Malek Al-Sabah    HRH Crown Prince Congratulates Santiago Peña on Winning Presidential Election in Paraguay    SDAIA Launches 1st Phase of 'Elevate Program' to Train 1,000 Women on Data, AI    41 Saudi Citizens and 171 Others from Brotherly and Friendly Countries Arrive in Saudi Arabia from Sudan    Saudi Arabia Hosts 1st Meeting of Arab Authorities Controlling Medicines    General Directorate of Narcotics Control Foils Attempt to Smuggle over 5 Million Amphetamine Pills    NAVI Javelins Crowned as Champions of Women's Counter-Strike: Global Offensive (CS:GO) Competitions    Saudi Karate Team Wins Four Medals in World Youth League Championship    Third Edition of FIFA Forward Program Kicks off in Riyadh    Evacuated from Sudan, 187 Nationals from Several Countries Arrive in Jeddah    SPA Documents Thajjud Prayer at Prophet's Mosque in Madinah    SFDA Recommends to Test Blood Sugar at Home Two or Three Hours after Meals    SFDA Offers Various Recommendations for Safe Food Frying    SFDA Provides Five Tips for Using Home Blood Pressure Monitor    SFDA: Instant Soup Contains Large Amounts of Salt    Mawani: New shipping service to connect Jubail Commercial Port to 11 global ports    Custodian of the Two Holy Mosques Delivers Speech to Pilgrims, Citizens, Residents and Muslims around the World    Sheikh Al-Issa in Arafah's Sermon: Allaah Blessed You by Making It Easy for You to Carry out This Obligation. Thus, Ensure Following the Guidance of Your Prophet    Custodian of the Two Holy Mosques addresses citizens and all Muslims on the occasion of the Holy month of Ramadan    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.



MOST CML PATIENTS ON GLEEVEC ALIVE AFTER 5 YEARS
Published in Saudi Press Agency on 03 - 06 - 2006

NEARLY 90 PERCENT OF PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA WHO WERE TREATED WITH NOVARTIS AG'S GLEEVEC WERE ALIVE AFTER FIVE YEARS, NEW DATA SHOWS, COMPARED TO THE NO MORE THAN 50 PERCENT SURVIVAL RATE WITH OTHER THERAPIES, REUTERS REPORTED.
DATA PRESENTED ON SATURDAY AT THE ANNUAL MEETING OF THE SOCIETY OF CLINICAL ONCOLOGISTS IN ATLANTA SHOWED THAT AT FIVE YEARS, THE OVERALL SURVIVAL OF 553 PATIENTS WHO RECEIVED GLEEVEC AS THEIR INITIAL THERAPY WAS 89 PERCENT.
"THIS TREND, IF IT HOLDS, COUPLED WITH THE LOW RISK OF RELAPSE, MEANS THAT THE POSSIBILITY OF LONG-TERM SURVIVAL WITH CML IS INCREASINGLY LIKELY," SAID DR. BRIAN DRUKER, WHO HELPED DEVELOP GLEEVEC AND IS A CHAIR OF LEUKEMIA RESEARCH IN THE OREGON HEALTH & SCIENCE UNIVERSITY CANCER INSTITUTE.
THE TYPICAL RATE OF SURVIVAL OF PATIENTS WHO TOOK OTHER THERAPIES WAS NO MORE THAN 50 PERCENT, INVESTIGATORS SAID.
THE TRIAL WAS BEGUN IN 2000 AND INVOLVED 1,106 SUBJECTS. HALF RECEIVED GLEEVEC AND HALF RECEIVED STANDARD TREATMENT AT THE TIME THE TRIAL STARTED -- INTERFERON-ALPHA AND CYTARABINE ARABINOSIDE. PARTICIPANTS WERE ALLOWED TO CROSS OVER TO THE GLEEVEC GROUP AND ONLY 3 PERCENT REMAIN ON INTERFERON.
GLEEVEC WAS APPROVED IN 2001 BY THE U.S. FOOD AND DRUG ADMINISTRATION. IN 2002 IT WAS APPROVED FOR GASTROINTESTINAL STROMAL TUMORS (GIST), A RARE FORM OF ABDOMINAL CANCER, IN 2002.
ABOUT 4,600 NEW CML CASES ARE DIAGNOSED EACH YEAR IN THE UNITED STATES, ACCORDING TO THE LEUKEMIA & LYMPHOMA SOCIETY.
ON FRIDAY, AN FDA ADVISORY PANEL RECOMMENDED THE AGENCY APPROVE AN EXPERIMENTAL BRISTOL-MYERS SQUIBB CO. PILL FOR PATIENTS WHO HAD FAILED OTHER TREATMENTS.
THE DRUG, SPRYCEL, REDUCED OR ELIMINATED LEUKEMIA CELLS IN SOME PATIENTS WHO HAD STOPPED RESPONDING TO GLEEVEC OR COULD NOT TOLERATE IT.
SO FAR IT IS UNKNOWN HOW LONG THE EFFECTS LAST OR WHETHER PATIENTS LIVE LONGER, FDA REVIEWERS SAID.


Clic here to read the story from its source.