U.S. stocks fell sharply on Thursday, with the major indexes shedding more than 1 percent, as a drop in crude oil prices hurt shares of big energy companies, including Exxon Mobil Corp, Reuters reported. Disappointing results from Pfizer Inc. pushed the stock of the world's biggest drugmaker down over 8 percent, weighing on the Dow average and health-related stocks. Based on the latest available figures, the blue-chip Dow Jones industrial average was down 133.19 points, or 1.28 percent, to end unofficially at 10,280.94. The broad Standard & Poor's 500 Index was down 17.94 points, or 1.50 percent, at 1,177.82. The technology-laced Nasdaq Composite Index was down 23.13 points, or 1.11 percent, at 2,068.11.