In a rare break with President George W. Bush and anti-abortion conservatives, U.S. Senate Majority Leader Bill Frist on Friday endorsed legislation that would expand federally funded embryonic stem cell research, Reuters said. Frist, a Tennessee Republican and surgeon who may seek his party's presidential nomination in 2008, endorsed a bill already passed by the U.S. House of Representatives that would overturn the limits on the research Bush imposed in 2001. His backing, which could alienate the most staunchly anti-abortion conservatives but attract support from moderates in a potential White House bid, significantly improves chances of the legislation passing. Bush has vowed to veto the legislation because embryos are destroyed when the stem cells are extracted. White House spokesman Scott McClellan said Bush had not wavered in his moral opposition to the research but when Frist informed him of his decision by telephone on Thursday night, the president told him, "You've got to vote your conscience." Patients suffering from diabetes, Parkinson's disease, spinal cord injuries and other debilitating and life-threatening disorders have been clamoring for more federal dollars for stem cell research. Opinion polls show growing support for its expansion, even among many conservatives like Frist who generally oppose abortion.