European shares edged lower at the open on Wednesday, led by Royal Bank of Scotland, which slipped after a high-profile executive departure, as uncertainty over the U.S. monetary policy curbed demand, reuters reported. Shares in Royal Bank of Scotland fell 1.6 percent after finance director Nathan Bostock resigned after just 10 weeks in the job, dealing a major blow to the group's turnaround efforts. It was the top faller on the pan-European FTSEurofirst 300 index, which was down 0.1 percent at 1,262.31 points at 0809 GMT. Stocks were also weighed down by uncertainty over the timing of a reduction in the Federal Reserve's equity-friendly stimulus programme, which led investors to continue to take profits after a solid rally in stocks this year.