A potentially definitive US response to allegations that the Syrian government has used chemical weapons is nearing, news agencies cited President Barack Obama as telling CNN in an interview. Asked by a CNN correspondent if the US is now facing a "more abbreviated time frame" on Syria, Obama said simply "yes." "Unlike some of the evidence we were trying to get earlier .. what we've seen is that this is clearly a big event of grave concern," Obama said in the interview. "There is no doubt that when you see chemical weapons used on a large scale it is very troublesome, and that starts getting to some core national interests that the US has ... to make sure weapons of mass destruction are not proliferating," he added.