INDIAN WELLS, California: Fifth seed Andy Murray, sixth-seeded David Ferrer and defending champion Ivan Ljubicic all fell by the wayside on a day of startling upsets at the Indian Wells ATP tournament Saturday. British world number five Murray was eliminated 7-6, 6-3 by American qualifier Donald Young, Spaniard Ferrer crashed out 7-6, 6-3 at the hands of Croat Ivo Karlovic and Ljubicic was beaten 5-7, 6-4, 6-2 by Argentine Juan Martin del Potro. Spanish world No. 1 and top seed Rafa Nadal, however, had little trouble with his opening match as he demolished South African qualifier Rik de Voest 6-0, 6-2 after just an hour on the showpiece center court. The 32-year-old Karlovic, whose 2010 season was cut short by six months due to Achilles surgery, powered down nine aces before sealing victory against Ferrer in 95 minutes. The Croat, who broke the fastest serve world record with a 251 kph (156 mph) blast during his country's Davis Cup tie against Germany in Zagreb last week, will next meet Frenchman Gilles Simon, who beat German Rainer Schuettler 6-3, 7-6. Croat Ljubicic, who upset American Andy Roddick 7-6, 7-6 in last year's final, won a tight opening set against del Potro before being broken once in the second and twice in the third. Del Potro, who won his eighth ATP title at last month's Delray Beach International Championships, will next meet Ukrainian Alexandr Dolgopolov, a 6-4, 6-4 winner against Romania's Victor Hanescu. In other matches, Sweden's fourth seed Robin Soderling fended off a late fightback by Germany's Michael Berrer to win 6-3, 7-6 while India's Somdev Devvarman upset 19th-seeded Cypriot Marcos Baghdatis 7-5, 6-0. On the women's side the tournament's top seed Caroline Wozniacki topped American wild card Sloane Stephens, 6-3, 6-2. Dinara Safina of Russia beat two-time tournament champion Daniela Hantuchova of Slovakia, 7-6 (2), 6-4. Safina next plays No. 4 Samantha Stosur of Australia, a 6-2, 6-2 winner over qualifier Laura Pous-Tio of Spain. In a matchup between two of China's top players, Peng Shuai upset seventh-seeded Li Na, 4-6, 6-3, 6-3. Also, eighth-seeded Victoria Azarenka of Belarus defeated Ekaterina Makarova of Russia, 6-4, 6-3, and Agnieszka Radwanska, the ninth seed from Poland, beat Iveta Benesova of the Czech Republic, 7-6 (5), 6