A Canadian study involving mice shows that anti-impotence pills might protect the hearts of people with a common form of muscular dystrophy, researchers said this week. Canadian researchers gave sildenafil, the active ingredient in drug maker Pfizer Inc's Viagra, to mice with an animal version of Duchenne muscular dystrophy, and found that it improved their heart performance. They said it would be premature to give Viagra to people with the disease, but said the results indicate the drug potentially could be used to prevent or delay heart failure in children with Duchenne muscular dystrophy. The mice were given doses of the drug comparable to those administered to treat erectile dysfunction in men. The study, published in the Proceedings of the National Academy of Sciences, showed that sildenafil cut the levels of damage to contracting heart muscle cells. “If you don't give the sildenafil, the heart of these mice doesn't function as well as normal mice, and they are more susceptible to stress-induced cell death,” said researcher Christine Des Rosiers of the Montreal Heart Institute.
