US drug makers stand ready to spend $150 million to help President Barack Obama overhaul health care this fall, according to numerous officials, a staggering sum that could dwarf attempts to derail Obama's top domestic priority. The White House and allies in Congress are well aware of the effort by Pharmaceutical Research and Manufacturers of America, a somewhat surprising political alliance, given the drug industry's recent history of siding with Republicans and the Democrats' disdain for special interests. The campaign, now in its early stages, includes television advertising under PhRMA's own name and commercials aired in conjunction with the liberal group, Families USA. Numerous people with knowledge of PhRMA's plans said they had been told it would likely reach $150 million and perhaps $200 million. They spoke on condition of anonymity, saying they were not authorized to divulge details. Additionally, the industry is the major contributor to Healthy Economy Now, which recently completed a $12 million round of advertising nationally and in several states. The ads were made by firms with close ties to Democrats and the White House and generally reflected the administration's changing rhetoric on health care. In an interview, Ken Johnson, senior vice president of PhRMA, said, “We will have a significant presence over the August recess, both on television and newspapers and on radio, but we have not finalized details for our fall campaign.” Ron Pollack, executive director of Families USA, said the partnership with the deep-pocketed drug industry is one of mutual self-interest, even though the two groups disagree on numerous issues. “We want to achieve coverage for everyone. For PhRMA, this would improve volume for prescription sales because everyone” would have better access to medicine, he said. Any health care bill that makes it to Obama's desk is expected to extend health insurance to the nearly 50 million who now lack it. That would mean a huge new pool of potential customers for drug companies and other health care providers. That, in turn, has created an incentive to offer concessions to the White House and lawmakers in hopes of shaping the bill, rather than simply opposing it. Drugmakers were the first group to reach agreement with the White House and Senate Finance Committee Chairman Max Baucus, a Montana Democrat, announcing several weeks ago that they would absorb $80 billion in costs over a decade. Even before the announcement, according to several individuals, the White House sought help from PhRMA in passing legislation.