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WHO meets on production of swine flu vaccine
By Maria Cheng and Frank Jordans
Published in The Saudi Gazette on 16 - 05 - 2009

As swine flu cases topped 6,600 worldwide, vaccine makers and other experts met Thursday at the World Health Organization to discuss the tough decisions that must be made quickly to fight the evolving virus.
Pharmaceutical companies are ready to begin making a swine flu vaccine — but as the virus may mutate, questions abound: How much should be produced? How will it be distributed? Who should get it?
The expert group's recommendations will be passed to WHO Director-General Margaret Chan, who is expected to issue advice to vaccine manufacturers and the World Health Assembly next week.
WHO's flu chief said the meeting of industry representatives and independent experts sought to answer questions including when to recommend to manufacturers that they switch from a seasonal vaccine to one that works against the pandemic strain.
“No big decisions, no announcements,” Keiji Fukuda told reporters after the meeting. “These are enormously complicated questions, and they are not something that anyone can make in a single meeting.”
But some feel the main decision has already been made.
“It's a foregone conclusion,” said David Fedson, a vaccines expert and former professor of medicine at the University of Virginia. “If we don't invest in an H1N1 (swine flu) vaccine, then possibly we could have a reappearance of this virus in a mild, moderate, or catastrophic form and we would have absolutely nothing.”
Most flu vaccine companies can only make one vaccine at a time: seasonal flu vaccine or pandemic vaccine. Production takes months and it is impossible to switch halfway through if health officials make a mistake.
Vaccine makers can make limited amounts of both seasonal flu vaccine and pandemic vaccine — though not at the same time — but they cannot make massive quantities of both because that exceeds manufacturing capacity.
“What is really going to be wrestled with is that seasonal influenza itself has a significant impact on people,” said Fukuda. “This is an infection which is estimated to kill some hundreds of thousands of people each year around the world, so there is a real trade-off if you just say we're going to stop making that vaccine.”
At the moment, health officials aren't sure how deadly swine flu is, and whether they will need more seasonal flu vaccine or swine flu vaccine.
And if the swine flu mutates, scientists aren't sure how effective a vaccine made now from the current strain will remain.
WHO estimates that up to 2 billion doses of swine flu vaccine could be produced every year, though the first batches wouldn't be available for four to six months.
The US Centers for Disease Control and Prevention is currently working on a “seed stock” to make the vaccine, which should be ready in the next couple of weeks. That will be distributed to manufacturers worldwide so they can start producing the vaccine.
WHO is also negotiating with vaccine producers like GlaxoSmithKline PLC to save some of their swine flu vaccine for poorer nations. Many rich nations like Britain, Canada, Denmark, France, Switzerland and the United States signed deals with vaccine makers years ago to guarantee them pandemic vaccines as soon as they're available.
As of Thursday, at least 33 countries reported more than 6,600 cases of swine flu worldwide, with 70 deaths.
The figures are based on tallies provided by national governments and WHO. According to the global body's pandemic alert level, the world is at phase 5 — out of a possible 6 — meaning that a global outbreak is “imminent.”
“It's a no-brainer,” Fedson said of the decision to make swine flu vaccine. “All that's being discussed now is the details of how to make sure you have enough seasonal flu vaccine and the logistics of making the switch to H1N1 vaccine production.”
While the vaccine question hangs in the air, WHO has given Indian pharmaceuticals giant Cipla the medical go-ahead to produce a generic version of the anti-viral medication Tamiflu. The drug, also known as oseltamivir, is one of two anti-virals shown to work against swine flu.
WHO said Cipla's generic version was as effective as the original made by Swiss firm Roche Holding AG and would hopefully make the drug more accessible to poor countries.
North America has been the hardest-hit continent. The United States has reported 3,352 laboratory-confirmed cases of swine flu, including four deaths. Arizona officials reported
Thursday the latest case, a woman in her late 40s who died last week from what appeared to be complications from the illness.
Mexico has 2,656 cases and 64 deaths, while Canada has 389 cases with one death, according to WHO figures.
Spain and Britain have the most cases in Europe, at 100 and 78 respectively.
In Central America, Costa Rica has eight cases and one death and Panama has 29 cases.


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