Andy Pettitte was roughed up in his first start following a rocky offseason, and the Tampa Bay Rays beat the New York Yankees 6-3 in the American League on Saturday. Pettitte was on a shorter-than-normal pitch count after he opened the season on the disabled list with back spasms. He lasted just five innings and was outpitched by Edwin Jackson (1-0), who allowed one run and five hits in six innings. It was Pettitte's first regular-season start since he admitted using human growth hormone and accused friend and former teammate Roger Clemens of also using HGH. Jonny Gomes homered and drove in four runs against Pettitte. Blue Jays 10, Red Sox 2: At Toronto, Frank Thomas hit a two-run homer, David Eckstein had three RBIs and Toronto used a six-run eighth inning to beat Boston for the sixth straight time. Jesse Litsch (1-0) allowed two runs on five hits over five innings for the win. He walked three – one intentional. Boston's Clay Buchholz (0-1) gave up four runs – three earned – and six hits over five innings. He struck out seven. Twins 6, Royals 4: At Minneapolis, Justin Morneau hit his first home run of the season and drove in four runs, and Livan Hernandez won his second straight start for Minnesota. Hernandez (2-0) pitched seven solid innings as the Twins won their second consecutive game against Kansas City, which started the season 3-0. Hernandez allowed four runs and seven hits. Kansas City led 2-0 and Gil Meche (0-1) was off to a strong start for the Royals before giving up a three-run homer to Morneau in the fourth inning. White Sox 5, Tigers 3: At Detroit, Jim Thome hit an RBI double in the sixth inning for Chicago's only hit off Dontrelle Willis, and Chicago beat Detroit, the only winless team in the major leagues. Detroit is 0-5 for the first time since the Tigers dropped their first nine games in 2003 en route to an AL-record 119 losses. Willis was wild in his Tigers debut, walking seven in five-plus innings. He gave up three runs in the White Sox's four-run sixth. In other games it was: Athletics 6, Indians 1; Orioles 6, Mariners 4; Angels 2, Rangers 1.Young hits 2 homers The Arizona Diamondbacks spoiled the unveiling of the Colorado's National League championship banner by beating the Rockies 7-2 in Denver on Saturday. Chris Young hit two homers and Brandon Webb (2-0) allowed only one earned run and five hits over seven innings for the Diamondbacks. Justin Upton had a solo homer in the second inning, his third of the season, and two singles. The Rockies, who finished off the regular season last year by winning 14 of their final 15 games, have dropped four in a row. Colorado is last in the majors with eight runs. Elsewhere in the National League it was: Brewers 5, Giants 4; Reds 4, Phillies 3; Cardinals 5, Nationals 4; Cubs 9, Astros 7; Braves 11, Mets 5; Padres 4, Dodgers 1; Marlins 7, Pirates 3. __