Al Khaleej stuns Al Hilal with 3-2 victory, ending 57-match unbeaten run    Turki Al-Sheikh crowned "Most Influential Personality in the Last Decade" at MENA Effie Awards 2024    Saudi Arabia arrests 19,696 illegals in a week    SFDA move to impose travel ban on workers of food outlets in the event of food poisoning    GACA: 1029 complaints recorded against airlines, with least complaints in Riyadh and Buraidah airports during October    CMA plans to allow former expatriates in Saudi and other Gulf states to invest in TASI    11 killed, 23 injured in Israeli airstrike on Beirut    Trump picks billionaire Scott Bessent for Treasury Secretary    WHO: Mpox remains an international public health emergency    2 Pakistanis arrested for promoting methamphetamine    Move to ban on establishing zoos in residential neighborhoods    Moody's upgrades Saudi Arabia's credit rating to Aa3 with stable outlook    Al Okhdood halts Al Shabab's winning streak with a 1-1 draw in Saudi Pro League    Mahrez leads Al Ahli to victory over Al Fayha in Saudi Pro League    Saudi musical marvels takes center stage in Tokyo's iconic opera hall    Saudi Arabia and Japan to collaborate on training Saudi students in Manga comics Saudi Minister of Culture discusses cultural collaboration during Tokyo visit    Al Khaleej qualifies for Asian Men's Club League Handball Championship final    Katy Perry v Katie Perry: Singer wins right to use name in Australia    Sitting too much linked to heart disease –– even if you work out    Denmark's Victoria Kjær Theilvig wins Miss Universe 2024    Order vs. Morality: Lessons from New York's 1977 Blackout    India puts blockbuster Pakistani film on hold    The Vikings and the Islamic world    Filipino pilgrim's incredible evolution from an enemy of Islam to its staunch advocate    Exotic Taif Roses Simulation Performed at Taif Rose Festival    Asian shares mixed Tuesday    Weather Forecast for Tuesday    Saudi Tourism Authority Participates in Arabian Travel Market Exhibition in Dubai    Minister of Industry Announces 50 Investment Opportunities Worth over SAR 96 Billion in Machinery, Equipment Sector    HRH Crown Prince Offers Condolences to Crown Prince of Kuwait on Death of Sheikh Fawaz Salman Abdullah Al-Ali Al-Malek Al-Sabah    HRH Crown Prince Congratulates Santiago Peña on Winning Presidential Election in Paraguay    SDAIA Launches 1st Phase of 'Elevate Program' to Train 1,000 Women on Data, AI    41 Saudi Citizens and 171 Others from Brotherly and Friendly Countries Arrive in Saudi Arabia from Sudan    Saudi Arabia Hosts 1st Meeting of Arab Authorities Controlling Medicines    General Directorate of Narcotics Control Foils Attempt to Smuggle over 5 Million Amphetamine Pills    NAVI Javelins Crowned as Champions of Women's Counter-Strike: Global Offensive (CS:GO) Competitions    Saudi Karate Team Wins Four Medals in World Youth League Championship    Third Edition of FIFA Forward Program Kicks off in Riyadh    Evacuated from Sudan, 187 Nationals from Several Countries Arrive in Jeddah    SPA Documents Thajjud Prayer at Prophet's Mosque in Madinah    SFDA Recommends to Test Blood Sugar at Home Two or Three Hours after Meals    SFDA Offers Various Recommendations for Safe Food Frying    SFDA Provides Five Tips for Using Home Blood Pressure Monitor    SFDA: Instant Soup Contains Large Amounts of Salt    Mawani: New shipping service to connect Jubail Commercial Port to 11 global ports    Custodian of the Two Holy Mosques Delivers Speech to Pilgrims, Citizens, Residents and Muslims around the World    Sheikh Al-Issa in Arafah's Sermon: Allaah Blessed You by Making It Easy for You to Carry out This Obligation. Thus, Ensure Following the Guidance of Your Prophet    Custodian of the Two Holy Mosques addresses citizens and all Muslims on the occasion of the Holy month of Ramadan    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.



CVD, if goes unchecked, to harm economy: Study
Published in The Saudi Gazette on 30 - 06 - 2015

From left: Dr. Adel Bashandi, MSD Saudi Arabia Business Unit, director for cardiovascular & metabolic diseases department; Dr. Saleh Al Jasser, Consultant Endocrinologist, KFNG- Riyadh; and Prof. Murad Elmourad, Consultant Endocrinologist, King Saud University Hospital, Riyadh, Saudi Arabia


RIYADH — Cardiovascular disease (CVD) is now recognized as the leading cause of death and disability worldwide.
Along with the rapid socioeconomic growth in the Gulf countries, there has been a change in lifestyle such as an increased consumption of poor quality foods and the adoption of a sedentary lifestyle, and as a consequence the rates of CVD and associated risk factors among the Gulf population have also increased.
In the long term, if the disease is not controlled, it will eventually affect not just the patient, but the economy as a whole.
Against this backdrop, research and development studies continue to explore for treatment. Lately, MSD, known as Merck in the US and Canada, has announced the primary results of Tecos, a placebo-controlled study of the cardiovascular (CV) safety of MSD's DPP-4 inhibitor, Januvia (sitagliptin).
The results of trial evaluating cardiovascular outcomes (Tecos) show that sitagliptin does not increase the risk of cardiovascular events in a diverse group of patients with type 2 diabetes at high cardiovascular risk.
At a symposium held in Riyadh recently, medical professors who are CVD consultants themselves, said trial evaluating cardiovascular outcomes with Sitagliptin (TECOS) was an event-driven trial conducted in adults with type 2 diabetes and a history of cardiovascular (CV) disease in a usual care setting.
The trial was designed to assess the CV safety of long-term treatment with sitagliptin (JANUVIA) when added to existing therapy compared with placebo.
The primary composite CV outcome was the time to the first confirmed event of CV-related death, nonfatal myocardial infarction, nonfatal stroke, or hospitalization for unstable angina.
Treatment with sitagliptin, a DPP-4 inhibitor, versus placebo for median 3 years in 14,671 patients with type 2 diabetes (T2DM) and established cardiovascular (CV) disease showed non-inferiority for the primary composite cardiovascular endpoint of the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS), and no increase in hospitalization for heart failure in the sitagliptin group.
Researchers at the University of Oxford Diabetes Trials Unit (DTU) and the Duke Clinical Research Institute (DCRI) have found that among patients with T2DM and established CV disease, addition of sitagliptin to usual care did not impact on the risk for major adverse CV events, hospitalization for heart failure or adverse events.
Concerns about possible links between incretin-based therapies and effects on the pancreas have been raised. In TECOS, acute pancreatitis and pancreatic cancer were uncommon and not statistically significant different between groups.
Numerically, in the sitagliptin group there were more patients with acute pancreatitis and fewer patients with pancreatic cancer than in the placebo group.
Professor Rury Holman of Oxford University, Joint Chair of the study, commented 'TECOS provides reassurance that sitagliptin may be used safely to improve blood glucose levels in a diverse group of T2DM patients at high cardiovascular risk without impacting on rates of cardiovascular complications or heart failure.'
Professor Eric Peterson, DCRI Executive Director at Duke University and Joint Chair of the study, stated: 'TECOS is an excellent example of academic and industry collaborative research.'
Overall, the primary endpoint occurred in 11.4 per cent (n=839) of sitagliptin-treated patients compared with 11.6 per cent (n=851) of placebo-treated patients in the Intention-to-Treat (ITT) analysis, and in 9.6 per cent (n=695) of patients in both the sitagliptin and placebo groups in the Per Protocol (PP) analysis.
Tecos was designed, run, and analyzed independently by DTU and DCRI, in an academic collaboration with Merck & Co., Inc., Kenilworth, NJ, USA, (known as MSD outside the United States and Canada), who sponsored and funded the study. — SG


Clic here to read the story from its source.