CHICAGO — Highly touted Mets pitcher Noah Syndergaard made his major league debut but the right-hander was unable to prevent New York from suffering a 6-1 loss to the Chicago Cubs in the National League at Wrigley Field Tuesday. Syndergaard (0-1) allowed three runs and six hits in 5 1/3 innings. He worked out of jams in the third and fifth but allowed an RBI double to Starlin Castro and a two-run home run to Chris Coghlan in the sixth. Cubs right-hander Jake Arrieta pitched a season-high eight innings and allowed one run and three hits. He struck out 10 and walked two. Another highly touted youngster, Chicago rookie third baseman Kris Bryant, went 3-for-4, including a second home run in as many nights. Diamondbacks 14, Nationals 6: Arizona right fielder Mark Trumbo hit two home runs and drove in four while third baseman Aaron Hill had three hits and two RBIs in the Diamondbacks' 14-6 victory over Washington at Chase Field. Trumbo hit a three-run homer to cap a five-run fourth inning off right-hander Stephen Strasburg (2-4) and added a bases-empty homer in the sixth. He has four homers and eight RBIs in five games in the number two spot in the lineup. Outfielder Clint Robinson became the first position player in Nationals history to pitch when the first baseman came in to record a scoreless eighth. Pirates 7, Phillies 2: A.J. Burnett celebrated the 12th anniversary of his no-hitter by pitching seven strong innings for Pittsburgh in a win over Philadelphia. Now 38 and in his 17th season, Burnett scattered six hits and allowed two runs (one earned). He struck out five and walked one — eight fewer than his no-hitter for the Florida Marlins in San Diego. Reds 4, Braves 3: Devin Mesoraco came through with a pinch-hit double in the bottom of the ninth inning and Cincinnati edged Atlanta. Todd Frazier hit his sixth home run in his last 13 games for the Reds, moving into a tie with Washington's Bryce Harper for the league lead. In another game, LA Dodgers beat Miami Marlins 11-1. American League Tigers 2, Twins 1 (10 innings): Ian Kinsler slapped an opposite field single to bring home center fielder Anthony Gose in the 10th inning as Detroit edged Minnesota. Detroit scored two runs or less for the third straight game but Kinsler collected his fifth career walk-off hit and second of the season. Blue Jays 10, Orioles 2: Mark Buehrle beat Baltimore for the fifth straight time and Edwin Encarnacion homered twice in a comfortable win for Toronto. Buehrle allowed two runs and four hits in six innings, while Josh Donaldson also got his team-leading eighth home run for the Blue Jays, who have scored 10 or more runs in four of eight games against Baltimore this season. Rays 4, Yankees 2: Tampa Bay scored two runs in the seventh inning and two runs in the eighth and rallied for their second win in eight meetings with the New York Yankees this season. Tampa Bay tied it on a two-run single by David DeJesus. The Rays took the lead on a sacrifice fly by Evan Longoria and a wild pitch by Dellin Betances. Other results: A's 9, Red Sox 2; Royals 7, Rangers 6 (10 innings). Inter-League Cardinals 8, Indians 3: Matt Holliday hit a three-run home run in the eighth inning as St Louis scored all its runs in a win over Cleveland with two outs. Mark Reynolds collected three hits for St Louis, which improved the best record in the major leagues to 23-9. The Cardinals are off to their best 32-game start since the 1941 team had the same mark. White Sox 4, Brewers 2: Chris Sale struck out 11 in eight innings and the Chicago White Sox rallied late to get past Milwaukee. In his return from a five-game suspension, Sale (3-1) allowed two runs and three hits. Other results: Giants 8, Astros 1; Angels 5, Rockies 2; Mariners 11, Padres 4. — Agencies