Harris allies point fingers at Biden for election defeat    Trump victory 'major setback' to climate action    Australia plans social media ban for under-16s    German coalition collapses after Scholz fires key minister    Liam Payne's body to be flown back to the UK    HRT does not impact life expectancy — UK health body    Neymar suffers muscle tear, out for 4-6 weeks    Suspect arrested for banking fraud totaling SR493 million as Nazaha pursues corruption charges    Arab leaders and heads of state congratulate US President-elect Donald Trump    Crown Prince, Pakistan Army Chief discuss ways to enhance military cooperation    Crown Prince aspires to strengthen strategic US-Saudi ties in call with Trump    Crown Prince hails Saudi medical team that performed world's first fully robotic heart transplant    Heavy Equipment and Truck Show to spotlight Tata Motors' cutting-edge mobility solutions    IKEA Alsulaiman opens Madinah store as part of an ambitious expansion plan in the Kingdom    Prince Badr signs MoUs with Al-Qasabi and Al-Falih to empower entrepreneurs and boost investments in cultural sector    Quality of life of Madinah residents and enriching visitor experience highlighted in Cairo event    Al Nassr secures 5-1 victory over Al Ain to edge closer to knockout stage    Top climber falls to death after rare Himalayan feat    Al Ahli extends perfect start with 5-1 victory over Al Shorta    Mitrovic's hat-trick leads Al Hilal to 3-0 victory over Esteghlal    India puts blockbuster Pakistani film on hold    The Vikings and the Islamic world    Filipino pilgrim's incredible evolution from an enemy of Islam to its staunch advocate    Muted Eid celebrations for millions of Nigerian Muslims    Exotic Taif Roses Simulation Performed at Taif Rose Festival    Asian shares mixed Tuesday    Weather Forecast for Tuesday    Saudi Tourism Authority Participates in Arabian Travel Market Exhibition in Dubai    Minister of Industry Announces 50 Investment Opportunities Worth over SAR 96 Billion in Machinery, Equipment Sector    HRH Crown Prince Offers Condolences to Crown Prince of Kuwait on Death of Sheikh Fawaz Salman Abdullah Al-Ali Al-Malek Al-Sabah    HRH Crown Prince Congratulates Santiago Peña on Winning Presidential Election in Paraguay    SDAIA Launches 1st Phase of 'Elevate Program' to Train 1,000 Women on Data, AI    41 Saudi Citizens and 171 Others from Brotherly and Friendly Countries Arrive in Saudi Arabia from Sudan    Saudi Arabia Hosts 1st Meeting of Arab Authorities Controlling Medicines    General Directorate of Narcotics Control Foils Attempt to Smuggle over 5 Million Amphetamine Pills    NAVI Javelins Crowned as Champions of Women's Counter-Strike: Global Offensive (CS:GO) Competitions    Saudi Karate Team Wins Four Medals in World Youth League Championship    Third Edition of FIFA Forward Program Kicks off in Riyadh    Evacuated from Sudan, 187 Nationals from Several Countries Arrive in Jeddah    SPA Documents Thajjud Prayer at Prophet's Mosque in Madinah    SFDA Recommends to Test Blood Sugar at Home Two or Three Hours after Meals    SFDA Offers Various Recommendations for Safe Food Frying    SFDA Provides Five Tips for Using Home Blood Pressure Monitor    SFDA: Instant Soup Contains Large Amounts of Salt    Mawani: New shipping service to connect Jubail Commercial Port to 11 global ports    Custodian of the Two Holy Mosques Delivers Speech to Pilgrims, Citizens, Residents and Muslims around the World    Sheikh Al-Issa in Arafah's Sermon: Allaah Blessed You by Making It Easy for You to Carry out This Obligation. Thus, Ensure Following the Guidance of Your Prophet    Custodian of the Two Holy Mosques addresses citizens and all Muslims on the occasion of the Holy month of Ramadan    







Thank you for reporting!
This image will be automatically disabled when it gets reported by several people.



Hope for loved ones lost to Alzheimer's
Published in The Saudi Gazette on 07 - 03 - 2015


Amal Al-Sibai
Saudi Gazette


Cindy is losing her mother, day by day, but not physically. Cindy says about her mom, “I open the door and see my mom in her wheelchair, scooting to various locations about the room.
It has become increasingly difficult to visit, as she no longer recognizes me and her speech has been replaced by very bizarre utterances.
My mom has Alzheimer's disease, and she is in its final stage. My dream at this time is a more effective treatment for Alzheimer's. A cure would be incredible, but I would settle for a better treatment.”
Recently, news reports have announced that there seems to be a glimmer of hope, if not for Cindy's mom, at least for Alzheimer's disease patients in the early stages, whose condition has not progressed. A new treatment is just on the horizon.
To understand how this touted treatment works, the physical changes that occur in the brain of an Alzheimer's disease patient must be understood first.
Certain protein structures are seen in higher concentrations in MRI images of the brains of Alzheimer's disease patients, far more than in the brains of healthy (dementia-free) patients.
These structures called amyloid fibrils are proteins that have the tendency to clump together in the brain, they fold into the wrong shape and form into twisted, tangled structures.
These tangles, also called amyloid plaques, block the supply of nutrients and other essential supplies to nerve cells, and the nerve cells eventually die.
Tangles spread, appearing in larger numbers as the dementia gets worse. In the beginning the victim of Alzheimer's disease may have problems remembering where he left his car keys or recalling the names of familiar people.
But as the amyloid fibrils spread to other parts of the brain, the patient deteriorates. They may get confused and have trouble handling money, speaking, and organizing their thoughts, and they may experience personality changes. They lose basic social skills and the ability to care for themselves.
What has excited the scientific community is the finding of a molecular chaperone which can interfere with the step that produces these amyloid fibrils, possibly stopping the toxic chain reaction that leads to the death of brain and nerve cells.
Not a very easy concept to understand, but in simple terms, a molecular chaperone is a protein that assists in the folding or unfolding and in the assembly or disassembly of other normal structures on the cellular level.
When chaperones are present, these structures will perform normal biological functions, and no mishaps will occur in the development of these structures.
How is this going to slow down the progression of Alzheimer's disease? Well, the molecular chaperone is like the monitor to make sure that protein structures are synthesized correctly, eliminating the step where things could go wrong.
When things go wrong, proteins can develop into an abnormal structure, like amyloid fibrils, which is closely linked to Alzheimer's disease.
So, if scientists could pinpoint a molecular chaperone that can keep protein synthesis operating smoothly and normally, chances are they could reduce the formation of amyloid fibrils in the brain, thus treating or at least preventing Alzheimer's disease.
And this discovery was made by an international team of academics from the Department of Chemistry at the University of Cambridge, the Karolinska Institute in Stockholm, Lund University, the Swedish University of Agricultural Sciences, and Tallinn University.
Dr. Samuel Cohen, researcher and lead author of the report in the Natural Structural & Molecular Biology journal, said, “A great deal of work in this field has gone into understanding which microscopic processes are important in the development of Alzheimer's disease; now we are starting to reap the rewards of this hard work.
Our study shows, that for the first time, one of these critical processes being specifically inhibited, and reveals that by doing so we can prevent the toxic effects of protein aggregation that are associated with this terrible condition.”
“We were able to identify a molecule that produced exactly the results that we were hoping to see in experiments,” added Cohen.
Researchers identified the molecule, Brichos, which inhibits the step that leads to the out-of-control protein folding that produces the tangles in the brain, which have been shown to be so toxic in Alzheimer's disease sufferers.
The report further stated that Brichos is a molecular chaperone; it is like housekeeping molecules that help proteins avoid mis-folding and aggregation into structures that are toxic to brain cells, and are implicated in Alzheirmer's disease.
Although it may not be a miracle cure, scientists are hopeful and optimistic, that relief for Alzheimer's disease sufferers is on its way.
“A good tactic now is to search for other molecules that have this same highly targeted effect and to see if these can be used as the starting point for developing a future therapy,” said Cohen.
Sadly, Alzheimer's causes not only memory loss and loss of mental functions, but the person is lost as well.
It is extremely difficult on the caregivers and family members to see their loved ones slipping away from them, mentally and emotionally.
How to cope
The following are tried steps from the caregiver of an Alzheimer's victim, which he shared on the American Alzheimer's Association web-site, to help others cope, who are caring for a loved one with Alzheimer's.
1. It is vitally important for people with Alzheimer's disease to maintain a consistent daily routine. The daily life of an Alzheimer's patient must be maintained on a schedule with minimal or no changes if possible.
2. If still in the early stages of dementia, the more the exercise the mind can get, the slower the progression of the disease.
Encourage your loved one to read the newspaper, do a crossword puzzle, play a game of chess, state the date and day of the week each day, and read about and discuss current events.
3. Buy a calendar and nail it to the wall. With a red marker, write any appointments necessary: doctor, haircut, social visit, to help all family members keep up to date on important appointments.
4. If your family member suffering from Alzheimer' is on medications, make sure she takes them at the proper time and at the same time each day. Preferable medicines should be taken with meals.
5. When your loved one does remember an appointment or remembers to wash up in the morning or makes herself a sandwich, positive reinforcement is vital when she completes what once used to be an easy task.
For people with Alzheimer's, doing some things on their own makes them feel more in control. They need to feel that they can still do things.
They need to be told you are proud of them as they complete tasks. When they say they do not want to do something, tell them you can't do it without their help or say, “Let's do it together.”
6. Resist the temptation to do everything for them just because it is easier or quicker. Patiently be firm that they still perform some tasks on their own. Again, positive reinforcement is vital.
The person with Alzheimer's needs to feel wanted, appreciated and, most of all, complimented when they find the courage to go on.
7. Give yourself some time to rest and accept help from supportive people when they offer.


Clic here to read the story from its source.