Showing the ultimate confidence in his offense, Denver coach Mike Shanahan went for a 2-point conversion with 29 seconds left. Jay Cutler hit rookie Eddie Royal over the middle to give the Denver Broncos a 39-38 win over the stunned San Diego Chargers on Sunday. The Chargers (0-2) couldn't believe they lost in the final seconds for the second straight week, with a controversial officiating call helping decide the outcome. Trailing 38-31, the Broncos (2-0) reached the 1, but on third-and-goal, Cutler reared back to throw. The ball slipped out of his hands, bounced off the grass and into linebacker Tim Dobbins' hands. But referee Ed Hochuli blew his whistle, apparently ruling it an incomplete pass. After a review, Hochuli said the Broncos would keep the ball because his whistle had blown the play dead. The Broncos got the ball at the 10, where it hit the grass. Cutler completed 36 of 50 passes for a career-best 350 yards and four TDs. Brandon Marshall set a franchise record with 18 catches for 166 yards in a magnificent return from his one-game suspension. 49ers 33, Seahawks 30, OT: At Seattle, Joe Nedney shook off a missed field goal as time expired in regulation and kicked a 40-yarder 4:40 into overtime. The loss left the four-time defending division champions 0-2 for the first time since 2002. San Francisco (1-1) overcame eight sacks of J.T. O'Sullivan to beat the Seahawks for just the third time in 11 games, in the first overtime game of the 19-game series between the two teams. Patriots 19, Jets 10: Matt Cassel was efficient running the offense in his first NFL start, taking over for the injured Tom Brady. Cassel, who hadn't started at any level since his senior year of high school, was 16-of-23 for 165 yards, Sammy Morris ran for a touchdown and Stephen Gostkowski kicked four field goals. The Patriots (2-0) ruined the Jets' home opener and Brett Favre's first regular-season home start for New York. New England won its 21st straight regular-season game, and beat the Jets for the eighth straight time at the Meadowlands. Favre went 18-of-26 for 181 yards and a TD for the Jets (1-1), but the Patriots took advantage of a big mistake by the veteran. Favre made a poor decision, hanging a pass intended for Chris Baker that was easily picked off by Brandon Meriweather for Favre's first interception with the Jets. Raiders 23, Chiefs 8: At Kansas City, Missouri, rookie Darren McFadden ran for 164 yards and a touchdown and Sebastian Janikowski kicked a team-record 56-yard field goal against an inept Chiefs team that tried three quarterbacks. Lane Kiffin, amid reports that his job is in jeopardy, won for just the fifth time 18 games as coach of the Raiders (1-1). The Chiefs' young defense gave up 300 yards rushing, including 90 by Michael Bush, who all by himself beat the Chiefs' 55 yards on the ground. Kansas City started 0-2 for the third time in three years under Herm Edwards and has lost 11 regular-season games in a row. Other results: Giants 41, Rams 13; Colts 18, Vikings 15; Packers 48, Lions 25;Steelers 10, Browns 6; Titans 24, Bengals 7; Bills 20, Jaguars 16; Panthers 20, Bears 17; Redskins 29, Saints 24; Cardinals 31, Dolphins 10; Buccaneers 24, Falcons 9.