Chinese President Xi Jinping has used a virtual summit with US counterpart Joe Biden to warn that encouraging Taiwanese independence would be "playing with fire", BBC reported. The talks are the most substantial since Biden took office in January. Both sides emphasized the two men's personal relationship and the summit was an attempt to ease tensions. But they could not escape one of the most sensitive topics: the self-ruled island of Taiwan. China sees Taiwan as a breakaway province to be reunified with the mainland one day. The US recognizes and has formal ties with China. But it has also pledged to help Taiwan defend itself in the event of an attack. China's state-run Global Times said Xi blamed recent tensions on "repeated attempts by the Taiwan authorities to look for US support for their independence agenda as well as the intention of some Americans to use Taiwan to contain China". "Such moves are extremely dangerous, just like playing with fire. Whoever plays with fire will get burnt," it said. The White House said Biden "strongly opposes unilateral efforts to change the status quo or undermine peace and stability across the Taiwan Strait". Despite the strong words on Taiwan, the meeting began with both leaders greeting each other warmly, with Xi saying he was happy to see his "old friend" Biden. Biden said the two had "always communicated with one another very honestly and candidly," adding "we never walk away wondering what the other man is thinking". Xi said the two countries needed to improve "communication" and face challenges "together". "Humanity lives in a global village, and we face multiple challenges together. China and the US need to increase communication and co-operation," said Xi. The world's two most powerful nations do not see eye-to-eye on a number of issues, and Mr Biden raised US concerns about human rights abuses in Hong Kong and against Uyghurs in the north-west region of Xinjiang. China accuses the US of meddling in its domestic affairs. On trade, Biden highlighted the "need to protect American workers and industries from the PRC's [People's Republic of China's] unfair trade and economic practices". Xi also appeared to have made a strong comment on the issue, with Reuters reporting that he had told Biden that the US needed to stop "abusing the concept of national security to oppress Chinese companies". Climate change was also discussed. Last week the two sprung a surprise by issuing a joint declaration to address climate change, at talks in Glasgow, Scotland. This was the third time the two leaders have spoken since Biden's inauguration in January. The talks lasted three-and-a-half hours, longer than expected. Xi has not left China in nearly two years, since the outbreak of the Covid-19 pandemic. The China-US relationship is crucial to both parties and the wider world, with Beijing having called repeatedly on the new administration in Washington to improve relations which deteriorated under Biden's predecessor, Donald Trump. Both men are facing domestic concerns, with Mr Biden's poll numbers slumping in the face of inflation, the threat of coronavirus and the chaotic withdrawal from Afghanistan. Xi is tackling energy shortages and a property crisis.