Qualifier Julie Coin registered the biggest upset in US Open women's history, sending world No. 1 and top seed Ana Ivanovic crashing out in the second round on Thursday. Coin, who is ranked 188th in the world, broke Ivanovic three times in the one hour, 57 minute match, clinching the victory on her third match point at the main Arthur Ashe Stadium. The 25-year-old Coin was making her Grand Slam debut after successfully coming through the qualifying round. She had tried but failed earlier this year to qualify for the Australian Open, French Open and Wimbledon. Ivanovic looked the more nervous of the two in the deciding third set. She posted a total of eight double faults and made 37 unforced errors to 26 for Coin. Ivanovic, of Serbia, converted just one of her eight break-point chances and didn't record an ace. She did managed to survive two match points before going down in a historic defeat. Previously the top seed at the US Open had not lost earlier than the third round. Coin moves through to the next round where she will play French countrywoman Amelie Mauresmo. Earlier former world number one Mauresmo pulled herself out of a hole to beat Estonian Kaia Kanepi 2-6, 6-4, 6-0 in the second round encounter. The two-time Grand Slam champion, seeded 32nd, trailed world number 43 Kanepi by a set and a break but rallied to score a win. Venus Williams looked set to hand Paraguay's Rossana De Los Rios the dreaded whitewash after winning the first seven games of their second round match but eventually cantered to a 6-0, 6-3 win. Russian Dinara Safina also appeared to be in a hurry to reach the last 32 and had it not been for her lapses in concentration, she would have beaten Italy's Roberta Vinci more emphatically than the 6-4, 6-3 scoreline. British sixth seed Andy Murray and American ninth seed James Blake also emerged unscathed but not before both were given scares. Murray narrowly avoided being stretched into a fifth set in his 6-4, 1-6, 7-5, 7-6 win over France's Michael Llodra, while Blake seemed set for another marathon encounter until his Belgian opponent Steve Darcis was forced to quit with a back injury. The American, a five-set winner in his opening match, was leading 4-6, 6-3, 1-0 on Thursday when Darcis retired. Among those to fall on day four included Hungarian 13th Agnes Szavay and Czech Nicole Vaidisova, seeded 20th. Italy's Tathiana Garbin beat Szavay 5-7, 6-2, 6-3 and Severine Bremond of France secured a 7-5, 6-3 win over Vaidisova. Williams has not reached a final outside Wimbledon for more than five years but showed that she could break that trend here. On Wednesday Jelena Jankovic Sofia Arvidsson of Sweden 6-3, 6-7 (5), 7-5 to progress to the third round. On the men's side Russian No. 5-seed Nikolay Davydenko downed Israeli Dudi Sela 6-3, 6-3, 6-3 and No.8 Andy Roddick beat French veteran Fabrice Santoro 6-2, 6-2, 6-2. In other feature men's matches, Australian Open finalist Jo-Wilfried Tsonga, the No. 19 seed of France, moved on with a 6-7 (3), 6-4, 6-2, 6-3 win over Spain's Santiago Ventura; and No. 18 Nicolas Almagro of Spain beat Canadian Frank Dancevic 6-3, 6-4, 7-5. No. 3 Svetlana Kuznetsova shook off an early break and rallied to a 7-6 (3), 6-1 victory over Romanian Sorana Cirstea. Safin fined for outburst Marat Safin has been fined $2,000 for unsportsmanlike conduct during his first-round win over American Vince Spadea at the US Open, the International Tennis Federation said on Thursday. Safin lost his temper and argued with umpire Carlos Bernades after he was controversially foot-faulted on a second serve late in the fourth set against Spadea on Tuesday. With Bernades refusing to overturn the call Safin swore at the official and for a while refused to play on. Safin eventually won the match in five sets.