Roger Federer breezed into the third round of the French Open for the 15th time on Wednesday by seeing off German lucky loser Oscar Otte, while 11-time champion Rafael Nadal and Stefanos Tsitsipas also progressed, but women's contender Kiki Bertens retired with illness. The 37-year-old Federer held off a persistent world No, 144 Otte, saving all four break points he faced in a 6-4, 6-3, 6-4 win on Court Philippe Chatrier. Next up for the 20-time Grand Slam title winner is a clash with Norway's Casper Ruud who put out Italian 29th seed Matteo Berrettini 6-4, 7-5, 6-3. "The Grand Slams are incredible. You can meet a player who qualified who (you) have not heard of before," said Federer, who last played at Roland Garros in 2015. "It was difficult, he really played a great match." Federer's only French Open trophy came in 2009, and 10 years on he faces a daunting task to grab a second, potentially needing to beat Tsitsipas, Nadal and world No. 1 Novak Djokovic in order to come out on top. Nadal continued the strong start to his bid for a record-extending 12th title with a comfortable victory over German qualifier Yannick Maden. The 32-year-old Nadal was in near total control against world No. 114 Maden bar some nervy moments in the third set, winning 6-1, 6-2, 6-4. The 17-time major champion will play Belgian 27th seed David Goffin in the last 32. "He (Maden) is a good player. He had already won four matches so was full of confidence," said Nadal, whose Roland Garros win-loss record now reads an incredible 88-2. The Spaniard wasted little time in wrapping up the first two sets on Court Suzanne Lenglen. Maden may have briefly allowed himself to dream of an outrageous upset when he twice broke to level at 3-3 and then 4-4 in the third set, but Nadal put him back in his place with two quick games to seal victory. Nadal appears to be hitting form at just the right time, after following three consecutive semi-final defeats on clay with the Italian Open title before arriving in Paris. He finished the match with 43 winners against just 23 unforced errors. Dutch women's fourth seed Kiki Bertens retired from her match with Viktoria Kuzmova with illness while trailing 3-1, 40-15. The 27-year-old, one of the favorites for the tournament, complained of shaking and a lack of energy before calling it quits, leaving Kuzmova with a third-round clash against British 26th seed Johanna Konta. Greek star Tsitsipas did not have things all his own way against Bolivia's Hugo Dellien on Court Simonne Mathieu, but managed to grind out a 4-6, 6-0, 6-3, 7-5 victory on his fourth match point. The sixth seed, who beat Federer en route to the Australian Open semi-finals earlier this year, will take on Serbia's Filip Krajinovic in his maiden appearance in the third round. "Once I got myself into the right mindset, things seemed to flow my way," said 20-year-old Tsitsipas. Elsewhere on Wednesday, 2015 champion Stan Wawrinka showed that he can not be ruled out of contention with an impressive 6-1, 6-4, 6-0 success against in-form Chilean Cristian Garin. The Swiss will play Bulgaria's Grigor Dimitrov next, after the former world No. 3 beat 11th seed Marin Cilic in a marathon encounter 6-7 (3-7), 6-4, 4-6, 7-6 (7-2), 6-3. Japan's Kei Nishikori overcame a sluggish start to see off local favourite Jo-Wilfried Tsonga 4-6, 6-4, 6-4, 6-4, and reach the third round of the French Open on Wednesday. The seventh seed looked tight in the opening set before finding his range on Court Philippe-Chatrier, rallying back from a break down in the fourth to advance in solid fashion. Nishikori will face Serbian 31st seed Laslo Djere for a place in the fourth round. Another Frenchman, Richard Gasquet, was also sent packing as he slumped to a 6-2, 3-6, 6-3, 6-4, defeat by Argentine Juan Ignacio Londero. A Gasquet victory would have guaranteed a French presence in the fourth round after the 20-year-old Corentin Moutet, Londero's next opponent, downed Argentine 19th seed Guido Pella 6-3, 6-1, 2-6, 7-5. Ukrainian Elina Svitolina will face 2016 champion Garbine Muguruza in the third round after the ninth seed's compatriot Kateryna Kozlova pulled out before their match with a viral infection. Spain's Muguruza, seeded 19th this year, eased to a 6-4, 6-1 victory over Swede Johanna Larsson. Second seed Karolina Pliskova also clinched a straight-sets win, beating Slovakia's Kristina Kucova 6-2, 6-2 to set up a tie with Croatian 31st seed Petra Martic. Last year's runner-up Sloane Stephens cruised through with a 6-1, 7-6 (7-3) win over Sara Sorribes Tormo. The former US Open champion, who lost to Simona Halep in the 2018 French Open final, will play Slovenia's Polona Hercog next after she edged out American Jennifer Brady 6-3, 6-7 (8-10), 6-4. Canadian teenager Bianca Andreescu quit the French Open on Wednesday, reportedly with a shoulder injury, handing America's Sofia Kenin a walkover into the third round. Indian Wells champion Andreescu, seeded 22, only returned to the tour in Paris having been sidelined since Miami in March with shoulder trouble. Kenin will face either Serena Williams or Kurumi Nara for a last-16 place. Safarova retires from the sport Czech Lucie Safarova, the 2015 French Open runner-up, said she retired from Tennis on Wednesday. Safarova, 32, played her last match in the doubles in Paris with Dominika Cibulkova, the pair losing to Kenin and Andrea Petkovic 6-4, 6-0 in the opening round. Safarova reached a career high of world No. 5 in the singles rankings in 2015. She also won the women's doubles' title at Roland Garros in 2015 and 2017. — Agencies