Argentina's Sergio Aguero (L), Lionel Messi (C) and Ezequiel Garay relax before the start of a training session in Buenos Aires, Argentina, Tuesday. Argentina will face Uruguay in a World Cup qualifying soccer game in Mendoza Friday. — AP BUENOS AIRES — Stopping Lionel Messi is the primary concern of South American teams facing Argentina in the World Cup qualifiers. This week it is Uruguay's turn. Argentina defends its lead in the South American group at home to Uruguay in Mendoza Friday (0100 GMT Saturday). After seven matches it has 14 points, one more than Colombia and Ecuador and two ahead of Uruguay and Chile.It will be looking to make amends for a poor performance in its last match, a 1-1 draw with Peru in Lima where Messi, who had scored 10 goals in his previous six internationals, had one of his quietest games for his country. South American champion Uruguay wants a second successive upset over its neighbor after its Copa America quarterfinal victory on penalties last year. Uruguay's coach Oscar Washington Tabarez does not believe in man-marking Messi, but rather in preventing Argentina from functioning in support of the Barcelona ace. “Messi is a great player, among the best seen in the history of football ... so I'm not going to say too much about that because it would be redundant,” Tabarez told reporters in Montevideo Tuesday. “But Messi has a team around him trying to ensure he shows all his potential. “So we have to work on and counter everything Argentina does for the ball to get to Messi and after Messi takes it try to mark him.” The Uruguayans, World Cup semifinalist in 2010, need to recover from a poor September when they lost 4-0 away to Colombia and only managed a 1-1 draw at home to Ecuador. Captain Diego Lugano believes this double away fixture will be the hardest trip for Uruguay, which plays Bolivia at high altitude in La Paz next week, in the 16-match qualifying series. “These are key (qualifying) points, much more so after the last double-header when we didn't do well,” Lugano said. “We're facing two matches that are surely the most difficult of the qualifying series. An Argentina-Bolivia sequence (away) is very hard and we're practically obliged to bring back some points,” the central defender said. Uruguay has to manage without left-wing back Alvaro Pereyra, who is suspended, and injured midfielders Diego Perez and Gaston Ramirez. Argentina, which beat Paraguay 3-1 at home then drew 1-1 away to Peru last month, welcome back Sergio Agüero but has lost fellow striker Ezequiel Lavezzi to injury. Midfielder Javier Mascherano said good results against Uruguay and then Chile away in Santiago four days later would put Argentina well on course for a berth in the 2014 finals in Brazil. “If we can get six out of six points it would be ideal and we would be well on track to qualifying, not certain but on the right track,” Mascherano said at Argentina's training base outside Buenos Aires. “For us, the match against Uruguay is a classic. The last ones we have played against them were very tight (and) if we win we'd go with more confidence to Chile.” The Chileans, whose coach Claudio Borghi is serving a four-match suspension for dissent, first travel to play Ecuador in the rarefied air of Quito nearly 3,000 meters above sea level Friday (2100 GMT). Colombia, with striker Falcao in red-hot scoring form, is at home to bottom team Paraguay in its favorite Caribbean cauldron in Barranquilla (2030 GMT) and Bolivia, at home in both fixtures, host Peru in La Paz (2000 GMT). Venezuela, in sixth place with 11 points having already played eight matches, has a bye at the halfway stage in the competition. — Agencies