Novak Djokovic of Serbia celebrates his victory over David Ferrer of Spain at the Australian Open Wednesday. — Reuters Semifinals: Djokovic vs Murray Federer vs Nadal MELBOURNE – Defending champion Novak Djokovic appeared physically unwell for much of his quarterfinal match but still beat David Ferrer 6-4, 7-6 (4), 6-1 to complete a blockbuster semifinal lineup at the Australian Open. He leads the top four men in tennis to the semis at Melbourne Park — Djokovic against No. 4 Andy Murray, who won his quarterfinal match earlier Wednesday 6-3, 6-3, 6-1 over Kei Nishikori of Japan. On Thursday, No. 2 Rafael Nadal plays No. 3 Roger Federer, the first time the two former top-ranked stars have met in a semifinal since the 2005 French Open. Djokovic rubbed the back of his upper left leg on several occasions, looked on the verge of being physically sick in the second set and buried his head in towels several times during breaks. During the third set, a tired-looking Djokovic sat down on a linesman's chair during a line-call video challenge by Ferrer. “I was lucky to get out of the second set, it was a big mental advantage to get two sets up,” Djokovic said. After the match, he appeared to play down any on-court physical difficulties, saying “you have to hang in there.” The Nadal-Federer semifinal matchup has been rarely possible because the pair held the top two spots for most of the time between 2005 and 2010, meaning they could only meet in the finals after being placed in opposite sides of the draw. Djokovic said he'd be watching the Nadal and Federer match like any tennis fan. On the women's side, former and reigning Wimbledon winners Maria Sharapova and Petra Kvitova — two of the three players who can take the No. 1 ranking a— advanced to the semifinals. Sharapova won 6-2, 6-3 Wednesday against fellow Russian Ekaterina Makarova, who knocked out five-time champion Serena Williams in the previous round. Kvitova reached the semifinals at Melbourne Park for the first time with a 6-4, 6-4 win over unseeded Italian Sara Errani. The other player who can reach No. 1 — third-seeded Victoria Azarenka — plays defending champion Kim Clijsters in the other semifinal Thursday. Sharapova must repeat her 2008 Australian title run if she is to take over the No. 1 spot from Caroline Wozniacki, who lost any chance of maintaining her top ranking when she lost in the quarterfinals to Clijsters. Kvitova only has to match or better Azarenka to take the top spot.