The Syrian regime's key ally Russia launched heavy airstrikes overnight on the outskirts of divided Aleppo city, slowing a "last-chance" assault by rebels seeking to break a government siege. The assault began on Sunday and is intended to ease the encirclement of the opposition-held east of Aleppo city, where an estimated 250,000 residents have been under regime siege since July 17. The Britain-based Syrian Observatory for Human Rights described it as the largest rebel attack in Aleppo since 2012, when fighting left the city roughly divided between opposition control in the east and regime forces in the west. But government troops backed by Russian warplanes have put up a fierce defense, the monitor said. "The Russian raids didn't stop all night on the front lines" there, said observatory head Rami Abdel Rahman. "This has slowed the offensive and allowed regime troops to retake five of the eight positions that rebels had taken since Sunday," he added. The strikes came despite an appeal by US Secretary of State John Kerry on Monday for Russia to "restrain" itself and its ally in Damascus from "offensive operations". Kerry said the regime attacks had prevented the warring parties from meeting for negotiations on Monday, the target date set for the regime and opposition forces to agree on the framework of a political transition. Moscow blasted criticism by Washington over its actions. "As soon as there is real headway in fighting terrorists, made by the Syrian government and army with our support, the Americans started... demanding that we stop fighting terrorists," Deputy Foreign Minister Sergei Ryabkov told RIA-Novosti agency. The Aleppo offensive groups fighters from Fateh Al-Sham Front, formerly Al-Qaeda affiliate Al-Nusra Front, the powerful Ahrar Al-Sham and other factions. The observatory said 50 rebels and allied militants had been killed since it began, as well as dozens of regime troops. Six people also died and 10 were wounded by mortar fire on regime-controlled districts of southwest Aleppo, it said. The official SANA agency said five people died. The route used by regime forces and civilians living in government-controlled parts of Aleppo runs through Ramussa, on its southwest outskirts, the main target of the rebel assault. Its capture would both cut off government forces and open a new route into the city for rebels. The observatory said at least 30 civilians had also been killed since Sunday in opposition bombardment of government-held southwestern districts of Aleppo. "This battle is the last chance for rebels. If they lose, it will be difficult for them to launch a new assault to break the siege," Abdel Rahman said. "For the regime also, it's a question of life or death. They've been preparing for this battle for months and it'll be a tough blow for its troops if they lose." Residents in east Aleppo have reported food shortages and rising prices since government troops seized the last remaining road into opposition-held districts of the city on July 17. Elsewhere in Aleppo province, the pbservatory said at least 11 people were killed in airstrikes believed to have been carried out by Russian warplanes on the rebel-held town of Atareb. In the town of Saraqeb, 50 km south of Aleppo, 24 people suffered breathing difficulties after a barrel bomb attack, the observatory said. Residents said the barrel bomb attack had used chlorine gas, but the monitor could not confirm this.