At least 60 people have been killed in three days of intense fighting in Syria's northern city of Aleppo, the Syrian Observatory for Human Rights said, marking an escalation of violence. The monitoring group said seven children and 10 women were among those killed in a series of air strikes by the government side and shelling attacks by insurgents since Friday. Meanwhile, a bomb blast in a Damascus suburb that is home to one of the holiest Shiite shrines in Syria killed eight people on Monday, according to a pro-government TV station and an activist-run monitoring group. Syrian state TV said the suicide bomber detonated his explosives-packed vehicle at a military checkpoint at the entrance to the Sayyida Zeinab suburb. Syria's Al-Ikhbariya TV station showed footage of a slight depression on a road near a checkpoint where the bomb was said to have gone off. The wreckage had already been removed. Allies of the embattled Damascus government have mobilized Shiite fighters from Iran, Iraq and Lebanon to fight on the side of President Bashar Assad's forces on the grounds of defending the shrine and preserving the country's religious plurality. A previous bombing in the Sayyida Zeinab suburb, claimed by the Daesh group, killed some 130 people in February. The Syrian uprising began with mostly peaceful protests in 2011, but a brutal government crackdown and the rise of an armed insurgency eventually plunged the country into a full-blown civil war. The fighting has killed more than 250,000 people, according to the United Nations, which stopped tracking casualties several months ago.