Markel Starks scored 16 of his career-high 20 points in the second half Wednesday night as No. 12 Georgetown snapped fourth-ranked Louisville's 20-game home winning streak with a 71-68 victory in the Big East opener for both teams. Louisville (12-1) had been one of six Division I teams that came into play Wednesday without a loss. The freshman Otto Porter had 14 points and 14 rebounds for Georgetown (11-1). Kyle Kuric scored 17 points for Louisville. Michigan State 80, Indiana 65: Keith Appling scored a career-high 25 points and sparked a 20-0 second-half run to help No. 16 Michigan State (12-2) hand No. 13 Indiana its first loss. Christian Watford had 26 points for the visiting Hoosiers (12-1) in the Big Ten opener for both teams. Syracuse 75, Seton Hall 49: Fab Melo collected 12 points and 10 blocks, both career highs, as top-ranked Syracuse opened its Big East Conference schedule by stifling Seton Hall. Dion Waiters scored 15 points for host Syracuse (14-0). Jordan Theodore led Seton Hall (11-2) with 14 points. UConn 60, South Florida 57: Jeremy Lamb made 8 of 11 shots from the field and scored 23 points, leading ninth-ranked Connecticut (11-1) to a Big East win at South Florida (7-7). It was the conference opener for both. Ohio St. 87, Northwestern 54: William Buford sank five 3-pointers en route to a career-high 28 points as No. 2 Ohio State (13-1) downed visiting Northwestern in the Big Ten opener for both teams. Dave Sobolewski had 10 points for the Wildcats (10-3). Kentucky 86, Lamar 64: No. 3 Kentucky (12-1) posted an easy win at home as Michael Kidd-Gilchrist gathered 18 points and 6 rebounds. Lamar dropped to 8-5. Baylor 54, Mississippi State: 52 Pierre Jackson scored the winning layup with 28 seconds left as No. 6 Baylor, playing at home, raised its record to 13-0. No. 15 Mississippi State fell to 12-2. Missouri State 77, Creighton 65: Missouri State opened defense of its Missouri Valley Conference title with an upset of No. 21 Creighton (10-2). Kyle Weems scored 31 points for the visiting Bears (8-5). UNLV 124, Cent. Aransas 75: The reserve Chace Stanback scored 29 points to lead seven double-figure scorers as No. 19 UNLV (14-2) overwhelmed visiting Central Arkansas (5-7).