European scientists Tuesday said they had identified a new way by which the malaria parasite survives in human blood, a finding that marks the latest laboratory advance against the disease. Malaria's death toll has declined by a fifth over the last decade thanks to better drugs and distribution of insecticide-treated mosquito nets, but still claims some 800,000 lives every year, mostly children under five in sub-Saharan Africa. Researchers from Britain and France said they had identified genes in the Plasmodium falciparum parasite which produce enzymes called kinases. Thirty-six kinases are needed for the parasite to develop in human blood cells, a key part of its complex life cycle, they reported in the journal Nature Communications. “We are now looking for drugs that... stop the protein kinases from working. If we find these drugs then we will have a new way of killing the malaria parasite,” said Christian Doerig of France's Institut National de la Sante et de la Recherche Medicale (Inserm). Andrew Tobin of Britain's University of Leicester said the search for a new weapon was vital, given the parasite's dismaying ability to build resistance against treatment. “It seems perfectly realistic to us that we can now develop novel anti-malaria drugs based on the findings that we have made — it certainly is a big moment in our fight against this terrible disease that mainly affects the world's poorest people,” he said in a press release issued by the university.
