BEIRUT: Hundreds of thousands of protesters flooded cities around Syria Friday in what activists described as the largest outpouring against the regime of President Bashar Al-Assad and a powerful message of the opposition's resolve. At least 14 people were killed in various clashes, activists said. The wildfire rage – flaring in dozens of places at the same time – further strained the resources of Assad's security forces and military as they also try to choke off a refugee wave into Turkey. The centerpiece of the latest protests – the central city of Hama – brings further complications for the government. Security forces moved outside Hama in early June after shootings that left 65 people dead, and now the streets appear fully under the sway of the opposition with an estimated 300,000 people gathering Friday in the central square, activists said. Crowd estimates and other details cannot be independently verified. But the protest surge Friday appeared to dwarf recent weeks as Assad's forces tried to wear down the opposition with relentless force. Syrian rights groups say more than 1,400 people have been killed, most of them unarmed protesters, since mid-March. The regime disputes the toll, blaming “armed thugs” and foreign conspirators for the unrest that has posed the most serious challenge to the Assad family's 40-year ruling dynasty in Syria. In Hama, anti-government crowds defiantly staked their claim to the city – which carries important symbolism to the opposition. In 1982, Assad's late father, Hafez Assad, stormed the city to crush an uprising, leaving between 10,000 and 25,000 people dead, rights groups say. Syria-based activist Mustafa Osso estimated 300,000 people joined the rally in Hama without any sign of security forces, which remained outside the city and appeared unwilling to risk major bloodshed again. In Lithuania, US Secretary of State Hillary Rodham Clinton called on Assad's regime to either begin a credible political reform process or “continue to see increasingly organized resistance.” “It doesn't appear that there's a coherent and consistent message coming from Syria,” Clinton told a news conference. Earlier, speaking at a meeting of the Community of Democracies in the Baltic state, Clinton said the clock was ticking for President Assad. “It is absolutely clear that the Syrian government is running out of time,” Clinton said during the two-day session of the informal grouping of more than 100 nations. In separate clashes, three people were killed during a military operation seeking to halt the flow of refugees heading across the border to Turkey, said Rami Abdul-Rahman, the London-based director of the Syrian Observatory for Human Rights. More than 10,000 Syrians have already taken shelter in refugee camps in Turkey to escape the violence. State-run Syrian TV aired footage of pro-government demonstrators in different parts of the country carrying Syrian flags and posters of Assad.